ArticleThe Biochemical journal1996
Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 296 citations in OpenAlex.
- Research on the GST gene family in Salix lindleyana reveals Trp162 and Pro202 as key amino acids controlling the release rate of GS-X.BMC plant biology · 2025Article
- Functional Analysis of GSTK1 in Peroxisomal Redox Homeostasis in HEK-293 Cells.Antioxidants (Basel, Switzerland) · 2023Article
- DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Isoniazid metabolism and hepatotoxicity.Acta pharmaceutica Sinica. B · 2016Review
- Assembly of adiponectin oligomers.Reviews in endocrine & metabolic disorders · 2014Review
- Catalytic and structural diversity of the fluazifop-inducible glutathione transferases from Phaseolus vulgaris.Planta · 2012Article
- Overlapping protective roles for glutathione transferase gene family members in chemical and oxidative stress response in Agrobacterium tumefaciens.Functional & integrative genomics · 2012Article
- A glutathione transferase from Agrobacterium tumefaciens reveals a novel class of bacterial GST superfamily.PloS one · 2012Article
- Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.Journal of medicinal food · 2011Article
- GST profile expression study in some selected plants: in silico approach.Molecular and cellular biochemistry · 2010Article
- Comprehensive expression analysis suggests overlapping and specific roles of rice glutathione S-transferase genes during development and stress responses.BMC genomics · 2010Article
- Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations.Molecular biology reports · 2010Article
- Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119.The Journal of biological chemistry · 2009Article
- A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase.BMC structural biology · 2007Article
- Contribution of the mu loop to the structure and function of rat glutathione transferase M1-1.Protein science : a publication of the Protein Society · 2006Article
- Delineation of xenobiotic substrate sites in rat glutathione S-transferase M1-1.Protein science : a publication of the Protein Society · 2005Article
- Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme.Protein science : a publication of the Protein Society · 2005Article
- A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major.The Biochemical journal · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a cDNA clone that encodes rat glutahione S-transferase (GST) subunit 13, a GST originally isolated from rat liver mitochondrial matrix by Harris, Meyer, Coles and Ketterer [(1991) Biochem. J. 278, 137-141]. The 896 bp cDNA contains an open reading frame of 678 bp encoding a deduced protein sequence of which the first 33 residues (excluding the initiation methionine residue) correspond to the N-terminal sequence reported by Harris et al. Hence like many other nuclear-encoded, mitochondrially located proteins, there is no cleavable mitochondrial presequence at the N-terminus. GST subunit 13 was originally placed into the Theta class of GSTs on the basis of sequence identity at the N-terminus; however, this is the only identity with the Theta class and in fact GST subunit 13 shows little sequence similarity to any of the known GST classes. Most importantly it lacks the SNAIL/TRAIL motif that has so far been a characteristic of soluble GSTs, although it does possess a second motif (FGXXXXVXXVDGXXXXXF) reported for GST-related proteins (Koonin, Mushegian, Tatusov, Altschul, Bryant, Bork and Valencia [(1994) Protein Sci. 3, 2045-2054]. Southern and Northern blot analyses of rat DNA and mRNA are consistent with GST subunit 13's being the product of a single hybridizing gene locus. Searches of EST databases identified numerous similar human DNA sequences and a single pig sequence. We have derived a human cDNA sequence from these EST sequences which shows a high nucleotide similarity (77%) to rat GST subunit 13. The largest open reading frame is identical in length with subunit 13 and yields a deduced protein sequence identity of 70%. Most unusually the 3' non-coding nucleotide sequence identity is also 77%. We conclude that these cDNAs belong to a novel GST class hereby designated Kappa, with the rat GST subunit 13 gene designated rGSTK1 and the human gene being called hGSTK1.
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