ArticleThe Journal of experimental medicine1996
Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 115 citations in OpenAlex.
- Activation of immune signals during organ transplantation.Signal transduction and targeted therapy · 2023Review
- Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain't That Peculiar (with Apologies to Marvin Gaye).Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- β-Adrenergic receptor mediated increases in activation and function of natural killer cells following repeated social disruption.Brain, behavior, and immunity · 2012Article
- Molecular recognition of paired receptors in the immune system.Frontiers in microbiology · 2012Article
- Article
- T-cell development and function are modulated by dual specificity phosphatase DUSP5.The Journal of biological chemistry · 2008Article
- Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions.Seminars in immunology · 2006Review
- Arrested natural killer cell development associated with transgene insertion into the Atf2 locus.Blood · 2006Article
- Regulation of natural killer cell function: a role for the NK cell's own MHC class I molecules.Medical microbiology and immunology · 2005Review
- Article
- MHC-dependent and -independent modulation of endogenous Ly49 receptors on NK1.1+ T lymphocytes directed by T-cell receptor type.Immunology · 2003Article
- Receptor/ligand avidity determines the capacity of Ly49 inhibitory receptors to interfere with T-cell receptor-mediated activation.Immunology · 2003Article
- Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D.The Journal of experimental medicine · 2003Article
- H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function.The Journal of experimental medicine · 2001Article
- In vivo natural killer cell activities revealed by natural killer cell-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Modulation of Ly49A receptors on mature cells to changes in major histocompatibility complex class I molecules.Immunology · 1998Article
- Developmentally regulated extinction of Ly-49 receptor expression permits maturation and selection of NK1.1+ T cells.The Journal of experimental medicine · 1998Article
- Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) cells and some T cells are endowed with receptors specific for class I major histocompatibility complex (MHC) molecules that can inhibit cellular effector functions. The function of the Ly49 receptor family has been studied in vitro, but no gene transfer experiments have directly established the role of these receptors in NK cell functions. We show here that transgenic expression of the H-2Dd-specific Ly49A receptor in all NK cells and T cells conferred class I-specific inhibition of NK cell-mediated target cell lysis as well as of T cell proliferation. Furthermore, transgene expression prevented NK cell-mediated rejection of allogeneic H-2d bone marrow grafts by irradiated mice. These results demonstrate the function and specificity of Ly49 receptors in vivo, and establish that their subset-specific expression is necessary for the discrimination of MHC-different cells by NK cells in unmanipulated mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.