ArticleThe Journal of experimental medicine1996
Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 123 citations in OpenAlex.
- Review
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- Thirty-five years since the discovery of chemotactic cytokines, interleukin-8 and MCAF: A historical overview.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Review
- DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling.Journal of leukocyte biology · 2022Article
- Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entity.Haematologica · 2022Article
- Regulation of emergency granulopoiesis during infection.Frontiers in immunology · 2022Review
- TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.Cell reports · 2021Article
- The Interface Between Inflammatory Mediators and MicroRNAs inFrontiers in cellular and infection microbiology · 2021Article
- Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?Stem cell reviews and reports · 2020Review
- The health status alters the pituitary function and reproduction of mice in aLife science alliance · 2020Article
- Identification of New Soluble Factors Correlated With the Development of Graft Failure After Haploidentical Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2020Article
- Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.The Journal of clinical investigation · 2019Article
- CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.Blood · 2016Article
- Modulation of Hematopoietic Chemokine Effects In Vitro and In Vivo by DPP-4/CD26.Stem cells and development · 2016Article
- Article
- Leukemia cells induce changes in human bone marrow stromal cells.Journal of translational medicine · 2013Article
- Regulation of neutrophil trafficking from the bone marrow.Cellular and molecular life sciences : CMLS · 2012Review
- CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow.The Journal of clinical investigation · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Expansion of mature neutrophils has been observed in mice lacking the murine interleukin (IL) 8 receptor homolog [mIL-8Rh(-/-)], and human (hu) IL-8 suppresses proliferation of primitive myeloid cells in vitro and in vivo. To evaluate involvement and relevance of murine IL-8 receptor homolog (mIL-8Rh) in negative regulation of myelopoiesis, we studied mIL-8Rh(-/-) and (+/+) mice raised in a normal or germ-free environment. Immature myeloid progenitors from mIL-8Rh(+/+) mice bred under normal or germ-free conditions were significantly suppressed in vitro by recombinant huIL-8, macrophage inflammatory protein (MIP)-1 alpha, platelet factor (PF) 4, interferon inducible protein (IP) 10, monocyte chemotactic peptide (MCP) 1, and H-ferritin. In contrast, progenitors from mIL-8Rh(-/-) mice were insensitive to inhibition by IL-8, but not to these other chemokines and H-ferritin. Mouse MIP-2, a ligand for mIL-8Rh, suppressed progenitors from normal but not mIL-8Rh(-/-) mice. Under normal environmental conditions, enhanced numbers of myeloid progenitors were found in femur, spleen, and blood of mIL-8Rh(-/-) compared with mIL-8Rh(+/+) mice. Numbers of myeloid progenitors were greatly decreased in mIL-8Rh(-/-)and (+/+) mice in germ-free conditions, and were either not significantly enhanced in mIL-8Rh(-/-) mice compared with (+/+) mice or were only moderately so. Differences in progenitors/organ between a germ-free and normal environment were greater for the mIL-8Rh(-/-) mice. These results document selective insensitivity of myeloid progenitor cells from mIL-8Rh(-/-) mice to inhibition by huIL-8 and mouse MIP-2 and a large expansion of myeloid progenitors in these mice, the latter effect being environmentally inducible. This provides strong support for a negative myeloid regulatory role played by the mIL-8Rh in vivo, whose active ligand may be MIP-2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.