ArticleThe Journal of experimental medicine1996
Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Deep profiling of B cells responding to various pathogens uncovers compartments in IgG memory B cell and antibody-secreting lineages.Science advances · 2025Article
- Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Targeting CD24 in Cancer Immunotherapy.Biomedicines · 2023Review
- Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes.Frontiers in immunology · 2023Article
- CD24: A Novel Target for Cancer Immunotherapy.Journal of personalized medicine · 2022Review
- CD24 as a Potential Therapeutic Target in Patients with B-Cell Leukemia and Lymphoma: Current Insights.OncoTargets and therapy · 2022Review
- The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells.Scientific reports · 2020Article
- Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice.Frontiers in immunology · 2020Article
- The role of CD24 in multiple myeloma tumorigenicity and effects of the microenvironment on its expression.Oncotarget · 2019Article
- Impaired bone healing at tooth extraction sites in CD24-deficient mice: A pilot study.PloS one · 2018Article
- CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in immunology · 2018Article
- CD24 induces changes to the surface receptors of B cell microvesicles with variable effects on their RNA and protein cargo.Scientific reports · 2017Article
- Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases.Clinical reviews in allergy & immunology · 2016Review
- CD24: A Rheostat That Modulates Cell Surface Receptor Signaling of Diverse Receptors.Frontiers in cell and developmental biology · 2016Article
- Dynamic regulation of CD24 expression and release of CD24-containing microvesicles in immature B cells in response to CD24 engagement.Immunology · 2015Article
- The CD24 protein inducible expression system is an ideal tool to explore the potential of CD24 as an oncogene and a target for immunotherapy in vitro and in vivo.The Journal of biological chemistry · 2011Article
- Review
- Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.Journal of neuroinflammation · 2005Article
- Tumour biological aspects of CD24, a mucin-like adhesion molecule.Journal of molecular histology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine heat-stable antigen (HSA) is a glycosyl-phosphatidylinositol-linked cell surface protein which has been implicated in cellular adhesion processes, the co-stimulation of CD4+ T cells, and B cell memory. We have recently demonstrated a significant reduction in pro-B and pre-B lymphocytes in transgenic mice that overexpress HSA. We now report that cross-linking HSA with the M1/69 monoclonal antibody induces the apoptosis of cultured B cell precursors in a stomal cell and cytokine-independent manner and that sensitivity to HSA-mediated cell death increases with developmental maturity. The cross-linking of HSA does not induce apoptosis in mature splenic B cells, but instead inhibits their ability to proliferate in response to anti-CD40 + IL-4. Taken together, these data implicate HSA as a potent negative regulator of B cell development and activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.