ArticleInternational journal of colorectal disease1996
Effect of insulin-like growth factor I (IGF-I) administration on the healing of colonic anastomoses in rats.
Article in International journal of colorectal disease, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pharmacological interventions for improved colonic anastomotic healing: a meta-analysis.World journal of gastroenterology · 2014Pooled it
- Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome.World journal of gastroenterology · 2022Article
- Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing.Gastroenterology research and practice · 2020Article
- Growth hormone abolishes the negative effects of everolimus on intestinal wound healing.World journal of gastroenterology · 2016Article
- The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing.Gastroenterology research and practice · 2010Article
- Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats.Digestive diseases and sciences · 2009Article
- Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.Surgery today · 2007Article
- Our 20-year experience with experimental colonic anastomotic healing.Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gastrointestinal tract is highly responsive to the tropic effect of growth hormone (GH). GH stimulates the healing of colonic anastomoses either directly or through insulin-like growth factor I (IGF-I) since specific GH receptor as well as IGF-I receptor have been demonstrated in colon.
aimTo determine whether exogenous treatment with IGF-I could stimulate the healing of left colonic anastomoses in rats.
methodsAfter colonic anastomotic operations adult rats were randomised to treatment with either IGF-I (500 mu g per day) or vehicle (controls). Anastomotic breaking strength and collagen deposition were determined at day after surgery.
resultsIGF-I treatment increased the anastomotic collagen content by 23% compared with controls. This resulted in a lower extensibility of the anastomosis (P < 0.05), whereas the anastomotic breaking strength did not differ between groups. The treatment resulted in a 3 fold increase in serum IGF-I of IGF-I treated rats, compared to controls. The postoperative body weight increased by 5% in the IGF-I rats from day 0 to day 3, while the control group had a weight loss of 2% in the same period (P < 0.001).
conclusionTreatment of colon-operated rats with IGF-I increased the postoperative body weight and stimulates the collagen deposition of left colonic anastomoses, whereas the anastomotic strength may be unaffected by IGF-I treatment.
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