ArticleArchives of dermatological research1996
Dermal cysts of the rhino mouse develop into unopened sebaceous glands.
Article in Archives of dermatological research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 20 citations in OpenAlex.
- Isolation and Culture of Skin-Derived Differentiated and Stem-Like Cells Obtained from the Arabian Camel (Animals : an open access journal from MDPI · 2019Article
- The role of androgen and androgen receptor in skin-related disorders.Archives of dermatological research · 2012Review
- Hairless is a nuclear receptor corepressor essential for skin function.Nuclear receptor signaling · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rhino mouse (hr(rh)hr(rh)) is a mutant strain characterized by a wrinkled and hairless skin with epidermal utriculi (pseudocomedones) and dermal cysts. The epidermal cysts have been extensively studied. The present work focused on the dermal cysts. By electron microscopy it was found that they appear on day 20 after birth and that they originate from a pool of undifferentiated epithelial cells of the deepest part of the initial follicular unit. Progressively, the number of cells in these islets increased and a central cavity was formed. Peripheral cells differentiated into sebocyte-like cells and outer root sheath cells. Staining with Oil Red O solution indicated accumulation of lipid material in the central cavity. The dermal cysts of the adult rhino mouse were isolated and purified in several steps including enzyme digestion, centrifugation, and separation on Nylex sieves. The integrity of the isolated cysts was confirmed by histology and electron microscopy. Study of their keratin polypeptide pattern by gel electrophoresis indicated that they express the mouse keratins 5, 14, 6 and 17. Neutral lipid analysis of the dermal cyst contents showed that they were mainly composed of cholesterol esters, wax esters, lipid fractions which migrate between triglycerides and cholesterol esters but very small amounts of triglycerides, cholesterol and ceramides. In conclusion, the present results demonstrate that dermal cysts of the rhino mouse have strong similarities with sebaceous glands and outer root sheath cells. These structures can easily be isolated and could therefore serve as a 'closed sebaceous gland' model to study the physiology or differentiation of the sebaceous gland, or the effects of pharmacological agents.
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