ArticleNucleic acids research1996
Genomic structure and expression of the murine Hmgi-c gene.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Decoding high mobility group A2 protein expression regulation and implications in human cancers.Discover oncology · 2024Review
- Mink1 regulates spemann organizer cell fate in the xenopus gastrula via Hmga2.Developmental biology · 2023Article
- CDK13-Mediated Cell Cycle Disorder Promotes Tumorigenesis of High HMGA2 Expression Gastric Cancer.Frontiers in molecular biosciences · 2021Article
- Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.Scientific reports · 2020Article
- HMGA Proteins in Hematological Malignancies.Cancers · 2020Review
- The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis.International journal of molecular sciences · 2020Review
- Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype inHaematologica · 2017Article
- Article
- Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer.Oncotarget · 2015Article
- Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice.Blood · 2014Article
- Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneity.Human molecular genetics · 2012Article
- Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription.Genes & development · 2011Article
- Article
- TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Molecular cancer · 2010Article
- High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma.Molecular cancer · 2007Article
- A new role for the oncogenic high-mobility group A2 transcription factor in myogenesis of embryonic stem cells.Oncogene · 2005Article
- Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.Leukemia · 2005Article
- Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene.Nucleic acids research · 2003Article
- The HMG I proteins: dynamic roles in gene activation, development, and tumorigenesis.Immunologic research · 2001Review
- Misexpression of wild-type and truncated isoforms of the high-mobility group I proteins HMGI-C and HMGI(Y) in uterine leiomyomas.The American journal of pathology · 1999Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The murine Hmgi-c gene, a member of the Hmgi gene family, contains five exons encompassing >110 kb of genomic DNA at the pygmy locus on mouse chromosome 10. Northern analysis identified a 4.1 kb transcript which contains a 324 bp open reading frame encoding a 12 kDa HMGI-C protein. Further analysis defined both the 5' and 3' untranslated regions of the Hmgi-c mRNA species as 658 and 2967 bp respectively. The HMGI-C protein has three consecutive AT hook DNA binding domains and an acidic domain, each of which are encoded by individual exons; such an organization is conserved among the HMGI gene family members from insects to mammals. Similar to the HMGI/Y proteins, the HMGI-C protein does not function as a typical transcriptional activator. Developmental studies revealed that the Hmgi-c gene is expressed predominantly during mouse embryogenesis. Since the human homolog is disrupted in a number of tumors, HMGI-C could play an important role in cell proliferation and differentiation during mammalian development.
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