ArticleNucleic acids research1996
A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- Development of Traditional Chinese Medicine in combination with EGFR Inhibitors against Cancer.Journal of Cancer · 2025Review
- Expression of EGFR isoform D is regulated by HER receptor activators in breast cancer cells.Biochemistry and biophysics reports · 2022Article
- EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer.Theranostics · 2021Article
- Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing.PLoS computational biology · 2017Article
- Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.Scientific reports · 2017Article
- Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy.International journal of molecular sciences · 2017Review
- Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance.International journal of molecular sciences · 2016Review
- Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts.Frontiers in aging neuroscience · 2016Article
- Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA.Journal of systematics and evolution · 2013Article
- EGFR exon-level biomarkers of the response to bevacizumab/erlotinib in non-small cell lung cancer.PloS one · 2013Article
- Nuclear translocation of type I transforming growth factor β receptor confers a novel function in RNA processing.Molecular and cellular biology · 2012Article
- Article
- Identification of an exon 4-deletion variant of epidermal growth factor receptor with increased metastasis-promoting capacity.Neoplasia (New York, N.Y.) · 2011Article
- EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.Nature medicine · 2011Article
- EGFR isoforms and gene regulation in human endometrial cancer cells.Molecular cancer · 2010Article
- Article
- Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation.Oncogene · 2001Article
- Alternative transcript initiation and novel post-transcriptional processing of a leucine-rich repeat receptor-like protein kinase gene that responds to short-day photoperiodic floral induction in morning glory (Ipomoea nil).Plant molecular biology · 2000Article
- Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and phosphatidylinositol 3-kinase.The Biochemical journal · 1999Article
- Alternative poly(A) site selection in complex transcription units: means to an end?Nucleic acids research · 1997Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The epidermal growth factor receptor (EGFR) is encoded by the c-erbB1 proto-oncogene and plays an important role in the control of cell growth and differentiation. To study the potential growth regulatory role of soluble EGF receptors, we have isolated cDNA clones encoding a truncated, secreted form of the human EGFR. The 5' sequence of this cDNA is identical to the EGFR transcript encoding the full-length receptor through exon 10. The unique 3' sequence encodes two additional amino acid residues before encountering an in-frame stop codon, a poly(A) addition site and a poly(A)+ tail. Sequence comparison with genomic DNA sequences demonstrates that this alternative transcript arises by read-through of a splice donor site. As a result, this transcript encodes a portion of the extracellular ligand-binding domain, but lacks the transmembrane domain and the intracellular tyrosine kinase catalytic domain present in the EGFR. Conditioned medium from transfected fibroblast cells contains a 60 kDa protein that is specifically immunoprecipitated by an EGFR monoclonal antibody. These findings demonstrate that alternative processing of the human EGFR transcript produces a secreted product composed of only the extracellular ligand-binding domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.