ArticleNucleic acids research1996
Transcriptional regulation of the Drosophila CycA gene by the DNA replication-related element (DRE) and DRE binding factor (DREF).
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- ZBED1/DREF: A transcription factor that regulates cell proliferation.Oncology letters · 2020Review
- DREF Genetically Counteracts Mi-2 and Caf1 to Regulate Adult Stem Cell Maintenance.PLoS genetics · 2019Article
- The Drosophila histone methyltransferase NSD is positively regulated by the DRE/DREF system.Genes & genomics · 2018Article
- Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers.PloS one · 2018Article
- Ankyrin domain of myosin 16 influences motor function and decreases protein phosphatase catalytic activity.European biophysics journal : EBJ · 2015Article
- The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway.Scientific reports · 2014Article
- Drosophila myeloid leukemia factor acts with DREF to activate the JNK signaling pathway.Oncogenesis · 2014Article
- Article
- Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1.Biochimica et biophysica acta · 2013Article
- Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle.Cell cycle (Georgetown, Tex.) · 2013Article
- The warts gene as a novel target of the Drosophila DRE/DREF transcription pathway.American journal of cancer research · 2012Article
- Article
- Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF.Nucleic acids research · 2009Article
- Two components of the Myb complex, DMyb and Mip130, are specifically associated with euchromatin and degraded during prometaphase throughout development.Mechanisms of development · 2008Article
- hDREF regulates cell proliferation and expression of ribosomal protein genes.Molecular and cellular biology · 2007Article
- Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase.The EMBO journal · 2005Article
- DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.Molecular and cellular biology · 2005Article
- Article
- Redox regulation of DNA binding activity of DREF (DNA replication-related element binding factor) in Drosophila.The Biochemical journal · 2004Article
- Characterization of dRFX2, a novel RFX family protein in Drosophila.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila gene for cyclin A is expressed in dividing cells throughout development. This expression pattern is similar to those of genes related to DNA replication, suggesting involvement of some common control mechanism(s). In the upstream region (-71 to -64 with respect to the transcription initiation site) of the CycA gene, we found a sequence identical to the DNA replication-related element (DRE; 5'-TATCGATA), which is important for high level expression of replication-related genes such as those encoding DNA polymerase alpha and proliferating cell nuclear antigen. Transient expression assays with chloramphenicol acetyltransferase (CAT) were carried out to examine the function of the DRE sequence of the CycA gene. Deletion or base substitution mutations resulted in an extensive reduction in CAT expression. Furthermore, monoclonal antibodies against DRE binding factor (DREF) diminished or supershifted the complex of the DREF and DRE-containing fragment. The results indicate that the Drosophila CycA gene is under the control of a DRE/DREF system, as are DNA replication-related genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.