ArticleBehavior genetics1996
Hypothetical quantitative trait loci (QTL) for circadian period of locomotor activity in CXB recombinant inbred strains of mice.
Article in Behavior genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 50 citations in OpenAlex.
- mGluR7 genetics and alcohol: intersection yields clues for addiction.Neurochemical research · 2011Article
- A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice.Journal of circadian rhythms · 2007Article
- Natural allelic variation in the temperature-compensation mechanisms of the Arabidopsis thaliana circadian clock.Genetics · 2005Article
- Mammalian circadian biology: elucidating genome-wide levels of temporal organization.Annual review of genomics and human genetics · 2004Review
- Genetics of narcolepsy and other sleep disorders.American journal of human genetics · 1997Review
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The locomotor activity of male mice (Mus musculus) of 13 CXB (BALB/cBy x C57BL/6J) recombinant inbred (RI) strains and their progenitor strains was monitored for 4 to 6 weeks by infrared photoelectric beams under constant dark. The circadian period (tau) of locomotor activity was calculated and used in quantitative trait locus (QTL) analysis of strains' means. Results were compared with potential QTL found in a previous study of the BXD RI series. The mean tau of 13 CXB RI mouse strains (three to six animals per strain) in constant dark had a unimodal distribution suggesting polygenic inheritance. A number of potential QTL were found for this trait. There were two associations at p < .001. H23 on chromosome 3 and Pmv16 on chromosome 16. A region of chromosome 1 was associated with tau in both CXB and BXD RI series. There was also a conjunction with a locus determined from QTL analysis of the previously reported tau of wheel running activity in seven CXB RI strains (Schwartz and Zimmerman, 1990).
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