ArticleProceedings of the National Academy of Sciences of the United States of America1996
A cdc5+ homolog of a higher plant, Arabidopsis thaliana.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 80 citations in OpenAlex.
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- Early Fruit Development Regulation-Related Genes Concordantly Expressed with TCP Transcription Factors in Tomato (Current issues in molecular biology · 2023Article
- Environmental Signals Act as a Driving Force for Metabolic and Defense Responses in the Antarctic PlantPlants (Basel, Switzerland) · 2022Article
- Rearrangement with the nkd2 promoter contributed to allelic diversity of the r1 gene in maize (Zea mays).The Plant journal : for cell and molecular biology · 2022Article
- Regulatory Networks of Flowering Genes inPlants (Basel, Switzerland) · 2022Article
- Modulation ofPlants (Basel, Switzerland) · 2020Article
- Two distinct nucleic acid binding surfaces of Cdc5 regulate development.The Biochemical journal · 2019Article
- Transcriptomic comparison reveals genetic variation potentially underlying seed developmental evolution of soybeans.Journal of experimental botany · 2018Article
- The Evolutionary History of R2R3-MYB Proteins Across 50 Eukaryotes: New Insights Into Subfamily Classification and Expansion.Scientific reports · 2015Article
- Structural and functional insights into the N-terminus of Schizosaccharomyces pombe Cdc5.Biochemistry · 2014Article
- Characterization of putative cis-regulatory elements in genes preferentially expressed in Arabidopsis male meiocytes.BioMed research international · 2014Article
- CDC5, a DNA binding protein, positively regulates posttranscriptional processing and/or transcription of primary microRNA transcripts.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- New cis-regulatory elements in the Rht-D1b locus region of wheat.Functional & integrative genomics · 2012Article
- The spliceosome-activating complex: molecular mechanisms underlying the function of a pleiotropic regulator.Frontiers in plant science · 2012Article
- Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunity.PLoS pathogens · 2009Article
- A census of human transcription factors: function, expression and evolution.Nature reviews. Genetics · 2009Review
- Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.Cell cycle (Georgetown, Tex.) · 2008Article
- Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms.Genes & development · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We cloned and characterized a cDNA corresponding to a cdc5+ homolog of the higher plant, Arabidopsis thaliana. The cDNA, named AtCDC5 cDNA, encodes a polypeptide of 844 amino acid residues. The amino acid sequence of N-terminal one-fourth region of the predicted protein bears significant similarity to that of Schizosaccharomyces pombe Cdc5 and Myb-related proteins. Overexpression of the AtCDC5 cDNA in S. pombe cells is able to complement the growth defective phenotype of a cdc5 temperature-sensitive mutant. These results indicate that the AtCDC5 gene is a plant counterpart of S. pombe cdc5+. This is the first report of a cdc5(+)-like gene in a multicellular organism. We also demonstrated that a recombinant AtCDC5 protein possesses a sequence specific DNA binding activity (CTCAGCG) and the AtCDC5 gene is expressed extensively in shoot and root meristems. In addition, we cloned a PCR fragment corresponding to the DNA binding domain of human Cdc5-like protein. These results strongly suggest that Cdc5-like protein exists in all eukaryotes and may function in cell cycle regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.