ArticleProceedings of the National Academy of Sciences of the United States of America1996
Spontaneous mutations recovered as mosaics in the mouse specific-locus test.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- A distributive germline restricts the spread of new mutations.bioRxiv : the preprint server for biology · 2026Article
- Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller's fruit fly findings, and Muller fails to cite Snell's findings.Archives of toxicology · 2024Article
- Linear Non-Threshold (LNT) historical discovery milestones.La Medicina del lavoro · 2022Article
- Genomic stability of mouse spermatogonial stem cells in vitro.Scientific reports · 2021Article
- The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing.Nature neuroscience · 2021Article
- Study logistics that can impact medical countermeasure efficacy testing in mouse models of radiation injury.International journal of radiation biology · 2021Article
- Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident.American journal of epidemiology · 2020Article
- In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?Environmental and molecular mutagenesis · 2020Article
- Similarities and differences in patterns of germline mutation between mice and humans.Nature communications · 2019Article
- Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate.Stem cells and development · 2016Article
- Direct estimate of the rate of germline mutation in a bird.Genome research · 2016Article
- A perspective on the evolution of germ-cell development and germinal mosaics of deleterious mutations.Genetica · 2015Review
- Somatic mosaicism: implications for disease and transmission genetics.Trends in genetics : TIG · 2015Review
- James V. Neel and Yuri E. Dubrova: Cold War debates and the genetic effects of low-dose radiation.Journal of the history of biology · 2015Article
- Precise estimates of mutation rate and spectrum in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Enhanced genetic integrity in mouse germ cells.Biology of reproduction · 2013Article
- Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants.Mutation research · 2012Review
- Genomic mutation rates: what high-throughput methods can tell us.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Review
- Article
- Chaos and order in spontaneous mutation.Genetics · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
The specific-locus test (SLT) detects new mutants among mice heterozygous for seven recessive visible markers. Spontaneous mutations can be manifested not only as singleton whole-body mutants in controls (for which we report new data), but as mosaics-either visible (manifesting mottled coat color) in the scored generation (G2) or masked, among the wild-type parental generation (G1). Masked G1 mosaics reveal themselves by producing clusters of whole-body mutants in G2. We provide evidence that most, if not all, mosaics detected in the SLT (both radiation and control progenies) result from a single-strand spontaneous mutation subsequent to the last premeiotic mitosis and before the first postmeiotic one of a parental genome-the "perigametic interval." Such events in the genomes of the G1 and Gzero results, respectively, in visible and masked 50:50 mosaics. Per cell cycle, the spontaneous mutation rate in the perigametic interval is much higher than that in pregamete mitotic divisions. A clearly different locus spectrum further supports the hypothesis of different origin, and casts further doubt on the validity of the doubling-dose risk-estimation method. Because mosaics cannot have arisen in mitotic germ cells, and are not induced by radiation exposure in the perigametic interval, they should not be included in calculations of radiation-induced germ-line mutation rates. For per-generation calculations, inclusion of mosaics yields a spontaneous frequency 1.7 times that calculated from singletons alone for mutations contributed by males; including both sexes, the multiple is 2.2.
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