ArticleMolecular & general genetics : MGG1996
Members of the pogo superfamily of DNA-mediated transposons in the human genome.
Article in Molecular & general genetics : MGG, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat.Nature ecology & evolution · 2018Article
- The origin and evolution of six miniature inverted-repeat transposable elements in Bombyx mori and Rhodnius prolixus.Genome biology and evolution · 2013Article
- The ant genomes have been invaded by several types of mariner transposable elements.Die Naturwissenschaften · 2012Article
- CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.Molecular and cellular biology · 2012Article
- Multiple waves of recent DNA transposon activity in the bat, Myotis lucifugus.Genome research · 2008Article
- Convergent domestication of pogo-like transposases into centromere-binding proteins in fission yeast and mammals.Molecular biology and evolution · 2008Article
- The evolutionary history of human DNA transposons: evidence for intense activity in the primate lineage.Genome research · 2007Article
- Diaspora, a large family of Ty3-gypsy retrotransposons in Glycine max, is an envelope-less member of an endogenous plant retrovirus lineage.BMC evolutionary biology · 2005Article
- A two-edged role for the transposable element Kiddo in the rice ubiquitin2 promoter.The Plant cell · 2005Article
- Isolation from the horse genome of a new DNA transposon belonging to the Tigger family.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Occan, a novel transposon in the Fot1 family, is ubiquitously found in several Magnaporthe grisea isolates.Current genetics · 2003Article
- Tc8, a Tourist-like transposon in Caenorhabditis elegans.Genetics · 2001Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new superfamily of transposons from fungi, nematodes, and flies related to the pogo element of Drosophila melanogaster was recognized that represents a branch of the extended superfamily of transposase and integrase proteins sharing a common D.D35E catalytic domain. Searches of human sequences in the public databases for similarity to this domain revealed at least two members of this new superfamily, with many highly mutated copies, in the human genome. A full-length consensus was constructed for one of them, which includes the MER37 medium reiteration frequency sequence recognized previously, from 343 human sequence accessions (261 of which are unique). Most of these were Expressed Sequence Tags, some were Sequence-Tagged Sites, and a few are from long genomic sequences. The 2417 bp consensus has the hallmarks of a pogo superfamily transposon, including 12 bp inverted terminal repeats, and encodes two long open reading frames. The first ORF encodes a polypeptide with 42% amino acid sequence identity to pogo in the D.D35E region. The second element shows 49% amino acid sequence identity with the first, and 40% with pogo in this region. These elements coincide with those described recently as Tigger1 and Tigger2, respectively. These transposons appear to have been active 80-90 Myr ago in the genome of an early primate or primate ancestor.
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