ArticleGenetics1996
Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The effect of mutation and selection on codon adaptation in Escherichia coli bacteriophage.Genetics · 2014Article
- Patterns of DNA-sequence divergence between Drosophila miranda and D. pseudoobscura.Journal of molecular evolution · 2009Article
- Ancient divergence in bathypelagic lake tanganyika deepwater cichlids: mitochondrial phylogeny of the tribe bathybatini.Journal of molecular evolution · 2005Article
- Article
- Isolation and characterization of the Xanthine dehydrogenase gene of the Mediterranean fruit fly, Ceratitis capitata.Genetics · 2001Article
- Substitution rates in Drosophila nuclear genes: implications for translational selection.Genetics · 2001Article
- Nonrandom spatial distribution of synonymous substitutions in the GP63 gene from Leishmania.Genetics · 2000Article
- Nucleotide polymorphism at the RpII215 gene in Drosophila subobscura. Weak selection on synonymous mutations.Genetics · 2000Article
- The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents.Genetics · 1999Article
- Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone.The Biochemical journal · 1999Article
- Synonymous rates at the RpII215 gene of Drosophila: variation among species and across the coding region.Genetics · 1999Article
- Chromosomal homologies between Drosophila melanogaster and D. funebris determined by in-situ hybridization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1999Article
- Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila.Genetics · 1999Article
- The correlation between synonymous and nonsynonymous substitutions in Drosophila: mutation, selection or relaxed constraints?Genetics · 1998Article
- Fate of dot chromosome genes in Drosophila willistoni and Scaptodrosophila lebanonensis determined by in situ hybridization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1998Article
- Article
- Chromosomal homology and molecular organization of Muller's elements D and E in the Drosophila repleta species group.Genetics · 1997Article
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2 authors.
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Abstract
The Xdh (rosy) region of Drosophila subobscura has been sequenced and compared to the homologous region of D. pseudoobscura and D. melanogaster. Estimates of the numbers of synonymous substitutions per site (Ks) confirm that Xdh has a high synonymous substitution rate. The distributions of both nonsynonymous and synonymous substitutions along the coding region were found to be heterogeneous. Also, no relationship has been detected between Ks estimates and codon usage bias along the gene, in contrast with the generally observed relationship among genes. This heterogeneous distribution of synonymous substitutions along the Xdh gene, which is expression-level independent, could be explained by a differential selection pressure on synonymous sites along the coding region acting on mRNA secondary structure. The synonymous rate in the Xdh coding region is lower in the D. subobscura than in the D. pseudoobscura lineage, whereas the reverse is true for the Adh gene.
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