ArticleBiophysical journal1996
Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 136 citations in OpenAlex.
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- Microneedle-Mediated Permeation Enhancement of Chlorhexidine Digluconate: Mechanistic Insights Through Imaging Mass Spectrometry.Pharmaceutical research · 2022Article
- Evaluation of Constrained and Restrained Molecular Dynamics Simulation Methods for Predicting Skin Lipid Permeability.ACS omega · 2021Article
- In Vitro Modeling of Skin Barrier Disruption and its Recovery by Ceramide-Based Formulations.AAPS PharmSciTech · 2021Article
- Electron Paramagnetic Resonance Gives Evidence for the Presence of Type 1 Gonadotropin-Releasing Hormone Receptor (GnRH-R) in Subdomains of Lipid Rafts.Molecules (Basel, Switzerland) · 2021Article
- Challenges and opportunities for small volumes delivery into the skin.Biomicrofluidics · 2021Article
- Probing Nanoscale Diffusional Heterogeneities in Cellular Membranes through Multidimensional Single-Molecule and Super-Resolution Microscopy.Journal of the American Chemical Society · 2020Article
- Effect of stratum corneum heterogeneity, anisotropy, asymmetry and follicular pathway on transdermal penetration.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters.Biology open · 2016Article
- Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study.Journal of colloid and interface science · 2016Article
- Wanted: scalable tracers for diffusion measurements.The journal of physical chemistry. B · 2014Review
- Infrared spectroscopic imaging tracks lateral distribution in human stratum corneum.Pharmaceutical research · 2014Article
- Energy-dependent uptake of benzo[a]pyrene and its cytoskeleton-dependent intracellular transport by the telluric fungus Fusarium solani.Environmental science and pollution research international · 2014Article
- FRAP in pharmaceutical research: practical guidelines and applications in drug delivery.Pharmaceutical research · 2014Review
- A microscopic multiphase diffusion model of viable epidermis permeability.Biophysical journal · 2013Article
- Glycosylation facilitates transdermal transport of macromolecules.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Delivery of molecular and cellular medicine to solid tumors.Advanced drug delivery reviews · 2012Article
- Influence of cancerostatic perifosine on membrane fluidity of liposomes and different cell lines as measured by electron paramagnetic resonance.Croatian medical journal · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
An image-based technique of fluorescence recovery after photobleaching (video-FRAP) was used to measure the lateral diffusion coefficients of a series of nine fluorescent probes in two model lipid bilayer systems, dimyristoylphosphatidylcholine (DMPC) and DMPC/cholesterol (40 mol%), as well as in human stratum corneum-extracted lipids. The probes were all lipophilic, varied in molecular weight from 223 to 854 Da, and were chosen to characterize the lateral diffusion of small compounds in these bilayer systems. A clear molecular weight dependence of the lateral diffusion coefficients in DMPC bilayers was observed. Values ranged from 6.72 x 10(-8) to 16.2 x 10(-8) cm2/s, with the smaller probes diffusing faster than the larger ones. Measurements in DMPC/cholesterol bilayers, which represent the most thorough characterization of small-solute diffusion in this system, exhibited a similar molecular weight dependence, although the diffusion coefficients were lower, ranging from 1.62 x 10(-8) to 5.60 x 10(-8) cm2/s. Lateral diffusion measurements in stratum corneum-extracted lipids, which represent a novel examination of diffusion in this unique lipid system, also exhibited a molecular weight dependence, with values ranging from 0.306 x 10(-8) to 2.34 x 10(-8) cm2/s. Literature data showed that these strong molecular weight dependencies extend to even smaller compounds than those examined in this study. A two-parameter empirical expression is presented that describes the lateral diffusion coefficient in terms of the solute's molecular weight and captures the size dependence over the range examined. This study illustrates the degree to which small-molecule lateral diffusion in stratum corneum-extracted lipids can be represented by diffusion in DMPC and DMPC/cholesterol bilayer systems, and may lead to a better understanding of small-solute transport across human stratum corneum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.