ArticleBiophysical journal1996
A theoretical study of calcium microdomains in turtle hair cells.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation.Physiological reports · 2020Article
- Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.Hearing research · 2019Review
- Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.The Journal of biological chemistry · 2014Article
- Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia.The Journal of physiology · 2013Article
- Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle.The Journal of physiology · 2013Article
- D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle.The Journal of general physiology · 2011Article
- Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle.The Journal of general physiology · 2011Article
- Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells.American journal of physiology. Cell physiology · 2011Article
- The diverse roles of ribbon synapses in sensory neurotransmission.Nature reviews. Neuroscience · 2010Review
- Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging.Nature neuroscience · 2009Article
- Tuning of synapse number, structure and function in the cochlea.Nature neuroscience · 2009Article
- Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Hair cell afferent synapses.Current opinion in neurobiology · 2008Review
- Interactions of recombinant mouse erythrocyte transglutaminase with membrane skeletal proteins.The Journal of membrane biology · 2007Article
- Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken.The Journal of physiology · 2007Article
- A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Confocal imaging has revealed microdomains of intracellular free Ca2+ in turtle hair cells evoked by depolarizing pulses and has delineated factors affecting the growth and dissipation of such domains. However, imaging experiments have limited spatial and temporal resolution. To extend the range of the results we have developed a three-dimensional model of Ca2+ diffusion in a cylindrical hair cell, allowing part of the Ca2+ influx to occur over a small circular region (radius 0.125-1.0 micron) representing a high-density array of voltage-dependent channels. The model incorporated experimental information about the number of channels, the fixed and mobile Ca2+ buffers, and the Ca2+ extrusion mechanism. A feature of the calculations was the use of a variable grid size depending on the proximity to the Ca2+ channel cluster. The results agreed qualitatively with experimental data on the localization of the Ca2+ transients, although the experimental responses were smaller and slower, which is most likely due to temporal and spatial averaging in the imaging. The model made predictions about 1) the optimal Ca2+ channel number and density within a cluster, 2) the conditions to ensure independence of neighboring clusters, and 3) the influence of the Ca2+ buffers on the kinetics and localization of the microdomains. We suggest that an increase in the mobile Ca2+ buffer concentration in high-frequency hair cells (which possess a larger number of release sites) would allow lower amplitude and faster Ca2+ responses and promote functional independence of the sites.
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