ArticleBritish journal of cancer1996
The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Drug resistance mechanisms in cancers: Execution of pro-survival strategies.Journal of biomedical research · 2024Article
- PXE, a Mysterious Inborn Error Clarified.Trends in biochemical sciences · 2019Review
- High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast.PloS one · 2015Article
- Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.The FEBS journal · 2011Review
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Development of a rapid, reliable genetic test for pseudoxanthoma elasticum.The Journal of molecular diagnostics : JMD · 2007Article
- Chromosome microdissection identifies genomic amplifications associated with drug resistance in a leukemia cell line: an approach to understanding drug resistance in cancer.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- Functions of yeast helicase Ssl2p that are essential for viability are also involved in protection from the toxicity of adriamycin.Nucleic acids research · 2004Article
- MRP subfamily transporters and resistance to anticancer agents.Journal of bioenergetics and biomembranes · 2001Review
- The novel genetic disorder microhydranencephaly maps to chromosome 16p13.3-12.1.American journal of human genetics · 2000Article
- MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver.British journal of cancer · 1999Article
- Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug-resistant leukaemia cell sublines.British journal of cancer · 1998Article
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Authors and funding
4 authors.
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Abstract
Multidrug resistance (MDR) in cancer cells is a major contributor to the failure of chemotherapy treatment. This paper describes a novel protein named the anthracycline resistance associated (ARA) protein. The ara gene is amplified in the MDR leukaemia line CCRF-CEM/E1000 and its mRNA is overexpressed. ARA belongs to the ATP binding cassette (ABC) family of proteins. Another ABC protein, the multidrug resistance-associated protein (MRP), has previously been reported to be overexpressed in the CEM/E1000 subline. The primary amino acid sequence of ARA indicates that it is 49.5 kDa without glycosylation, and that it has one potential glycosylation site. ARA has one ATP binding site and associated transmembrane regions. This is in contrast to MRP (190 kDa, 172 kDa deglycosylated) and most other higher eukaryote ABC proteins, which consist of two similar halves, each having one ATP binding site. In addition to ARA being coexpressed with MRP, comparison of amino acid sequences showed that, among known proteins, ARA is most similar to the C-terminal half of MRP.
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