Evidence map›Paper›PMID 8912467›Full record

ReviewWorld journal of urology1996

POU-domain gene expression during spermatogenesis.

A Zini, A Mielnik, P N Schlegel

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

A ZiniJames Buchanan Brady Foundation, Department of Urology, New York Hospital-Cornell Medical Center, NY 10021, USA.
A Mielnik
P N Schlegel
Cornell University · USNewYork–Presbyterian Hospital · USPopulation Council · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermatogenesis is an orderly process whereby male germ cells pass through sequential phases of differentiation to develop into mature spermatozoa. At present, little is known about the factors that regulate this process. The POU domain represents a group of transcription-activator proteins with well-described roles in development. These proteins have been shown to regulate the tissue-specific expression of genes involved in cellular differentiation. The recent identification of Sperm-1, a testis-specific POU-domain protein expressed in primary spermatocytes just prior to the onset of meiosis, suggests that this protein may be involved in the regulation of male germ-cell differentiation. Continued evaluation of Sperm-1 and other related transcriptional activators may shed some light on the regulation of spermatogenesis.

Indexed as

AnimalsBlotting, NorthernDNA-Binding ProteinsDNA ProbesGene ExpressionHumansMalePOU Domain FactorsRNA, MessengerSpermatogenesisTranscription FactorsTranscription, GeneticDNA-Binding ProteinsDNA ProbesPOU5F2 protein, humanPOU Domain FactorsRNA, MessengerTranscription Factors

Identifiers

PMID8912467
OpenAlexW1973313944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.