ArticleHistochemistry and cell biology1996
Enzyme-histochemical localization of carbonic anhydrase in the inner ear of the guinea pig and several improvements of the technique.
Article in Histochemistry and cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids.Current biology : CB · 2019Article
- Proton-mediated block of Ca2+ channels during multivesicular release regulates short-term plasticity at an auditory hair cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Scanning electrochemical microscopy as a novel proximity sensor for atraumatic cochlear implant insertion.IEEE transactions on bio-medical engineering · 2014Article
- Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter.The Journal of physiology · 2012Article
- Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.American journal of physiology. Renal physiology · 2007Article
- Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential.The Journal of physiology · 2006Review
- Distribution of pendrin in the organ of Corti of mice observed by electron immunomicroscopy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2006Article
- Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model.BMC medicine · 2004Article
- Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleas.Journal of the Association for Research in Otolaryngology : JARO · 2003Article
- Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have made several improvements in the method of fixation of the inner ear and the enzyme-histo-chemical technique for carbonic anhydrase (CA) detection. The results confirmed that CA is localized in the hair cells of the organ of Corti, Deiters' cells or nerve endings, inner pillar cells, Boettcher's cells, stria vascularis, spiral ligament, spiral limbus, and spiral ganglion cells. These results generally agree with previous histochemical observations but showed some differences. Our method preserved tissue morphology and showed more detailed localization of CA activity in the inner ear. In particular, the marginal zone of stria vascularis and the epithelial cells of spiral prominence, facing the endolymph, showed no CA activity, while the suprastrial region of the spiral ligament and the supralimbal region of the spiral limbus, juxtaposed to the perilymph, showed CA activity. In outer hair cells, the cuticular plate, which faces the endolymph showed CA activity, but the lateral membrane, which faces the perilymph showed no CA activity. In contrast, the inner hair cell cytoplasm showed diffuse CA activity. These results will be useful in considering ion exchange between endolymph and its adjacent cells, and between perilymph and its adjacent structures.
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