ArticleEuropean journal of applied physiology and occupational physiology1996
Glutathione-dependent modulation of exhausting exercise-induced changes in neutrophil function of rats.
Article in European journal of applied physiology and occupational physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 36 citations in OpenAlex.
- The impact of intermittent exercise in a hypoxic environment on redox status and cardiac troponin release in the serum of well-trained marathon runners.European journal of applied physiology · 2016Article
- Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation.Oxidative medicine and cellular longevity · 2016Article
- Diabetes, oxidative stress and physical exercise.Journal of sports science & medicine · 2002Review
- Antioxidants in exercise nutrition.Sports medicine (Auckland, N.Z.) · 2001Review
- Glutathione homeostasis in response to exercise training and nutritional supplements.Molecular and cellular biochemistry · 1999Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced glutathione (GSH) plays a central role in maintaining an effective synergism between various physiological and exogenous antioxidants. We tested the effects of GSH and N-acetylcysteine (NAC, a pro-GSH clinical drug), intraperitoneal (i.p.) supplementation and GSH deficiency on exercise-induced leucocyte margination and neutrophil oxidative burst activity. GSH, NAC (1g.kg-1) or placebo saline was i.p. injected (one or eight times) to male rats (n > or = seven per group). The GSH-deficient rats were prepared by i.p. injections of L-buthionine-[SR]-sulphoximine (BSO, 6 mmol.l-1.kg-1) twice daily for 4 days. Exercised animals were subjected to treadmill run to exhaustion. Exhausting treadmill exercise significantly decreased peripheral blood leucocyte count in the controls (P < 0.001). Such exercise-associated leucocyte margination was prevented by GSH supplementation. Peripheral blood neutrophil counts were significantly higher (P < 0.02) in the GSH-supplemented groups compared to the placebo control groups. Exercise-induced increase in peripheral blood neutrophil oxidative burst activity as measured by luminol-enhanced chemiluminescence per volume of blood tended to be higher in the GSH-supplemented group (P < 0.10), and lower in the GSH-deficient rats (P < 0.02). In these experiments, for the first time we have shown that GSH supplementation can induce neutrophil mobilization and decrease exercise-induced leucocyte margination, and that exogenous and endogenous GSH can regulate exercise-induced stimulation of the neutrophil oxidative burst.
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Registered trials
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