ArticleImmunology1996
Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells.
Article in Immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Review
- Aptamers that bind to the human complement component receptor hC5aR1 interfere with hC5aR1 interaction to its hC5a ligand.Molecular biology reports · 2018Article
- Complement Activation in Liver Transplantation: Role of Donor Macrosteatosis and Implications in Delayed Graft Function.International journal of molecular sciences · 2018Review
- Chemokine and chemotactic signals in dendritic cell migration.Cellular & molecular immunology · 2018Review
- Nerve Growth Factor Secretion From Pulp Fibroblasts is Modulated by Complement C5a Receptor and Implied in Neurite Outgrowth.Scientific reports · 2016Article
- The role of C5a in acute lung injury induced by highly pathogenic viral infections.Emerging microbes & infections · 2015Review
- Complement anaphylatoxins as immune regulators in cancer.Cancer medicine · 2014Review
- The role of the anaphylatoxins in health and disease.Molecular immunology · 2009Review
- Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.Infection and immunity · 2008Article
- S179D prolactin diminishes the effects of UV light on epidermal gamma delta T cells.Molecular and cellular endocrinology · 2008Article
- The role of complement in danger sensing and transmission.Immunologic research · 2006Review
- Expression of complement protein C5a in a murine mammary cancer model: tumor regression by interference with the cell cycle.Cancer immunology, immunotherapy : CII · 2005Article
- Molecular cloning and characterization of rainbow trout (Oncorhynchus mykiss) C5a anaphylatoxin receptor.Immunogenetics · 2003Article
- Up-regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2.Immunology · 2003Article
- The effect of locally synthesised complement on acute renal allograft rejection.Journal of molecular medicine (Berlin, Germany) · 2003Review
- Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin.Immunology · 2001Article
- Direct transfection and activation of human cutaneous dendritic cells.Gene therapy · 2001Article
- Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth.The Journal of clinical investigation · 2000Article
- Colonization of in vitro-formed cervical human papillomavirus- associated (pre)neoplastic lesions with dendritic cells: role of granulocyte/macrophage colony-stimulating factor.The American journal of pathology · 1999Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is known that dendritic cells (DC) migrate in response to inflammatory stimuli. There is little information about the expression of receptors for chemotactic factors on DC. The present study has demonstrated by double immunostaining and flow cytometry of Langerhan's cell (LC)-enriched epidermal cell suspensions that a small subpopulation (5-6%) of epidermal resident DC (rLC) expresses receptors for C5a (C5aR). Epidermal rLC positive for C5aR show a round-shape morphology, were located next to the basement membrane and express HLA-DR molecules higher than C5aR negative rLC. These observations suggest that rLC would express C5aR as part of their process of maturation during tissue trafficking. To investigate whether epidermal LC up-regulate C5aR along their differentiation pathway. LC were differentiated in vitro after culture in epidermal cell suspensions supplemented with granulocyte macrophage colony-stimulating factor (GM-CSF). As a result, in vitro differentiated LC increased the expression of C5aR up to 69% of the DC population. In accordance with this observation, interdigitating DC of secondary lymphoid organs (lymph node and tonsil) also expressed (5aR. Migratory CD1a positive DC that spontaneously migrated out of dermal or split-skin organ explants were also positive for C5aR and were used for chemotaxis and chemokinesis assays in response to human recombinant C5a (rC5a). Optimum migration to rC5a was observed at 10(-8)M with a sigmoidal dose response curve. Checkboard analysis demonstrated that locomotion in response to rC5a was chemotaxis and not chemokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.