ArticleThe Journal of physiology1996
Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 73 citations in OpenAlex.
- Histamine shapes the neurocomputational dynamics of human learning.Nature communications · 2026Article
- Histamine-3 Receptor Availability and Glutamate Levels in the Brain: A PET-1H-MRS Study of Patients With Schizophrenia and Healthy Controls.The international journal of neuropsychopharmacology · 2024Article
- The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia.Journal of psychopharmacology (Oxford, England) · 2023Article
- Histamine HBiological psychiatry · 2021Article
- Histamine HCellular and molecular neurobiology · 2021Article
- Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prenatal Alcohol Exposure Increases Histamine HAlcoholism, clinical and experimental research · 2018Article
- The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism.Translational psychiatry · 2017Article
- S 38093, a histamine HScientific reports · 2017Article
- Histamine HFrontiers in neural circuits · 2017Article
- International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.Pharmacological reviews · 2015Review
- Involvement of histaminergic inputs in the jaw-closing reflex arc.Journal of neurophysiology · 2015Article
- Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat.Frontiers in integrative neuroscience · 2014Article
- Single dose of H3 receptor antagonist--ciproxifan--abolishes negative effects of chronic stress on cognitive processes in rats.Psychopharmacology · 2014Article
- Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction.British journal of pharmacology · 2013Review
- Non-imidazole histamine HMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2013Article
- Review
- Histaminergic mechanisms for modulation of memory systems.Neural plasticity · 2011Review
- Acute pharmacological modulation of mGluR8 reduces measures of anxiety.Behavioural brain research · 2010Article
- Effects of the cognition-enhancing agent ABT-239 on fetal ethanol-induced deficits in dentate gyrus synaptic plasticity.The Journal of pharmacology and experimental therapeutics · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of histamine on excitatory synaptic transmission in the dentate gyrus region of rat hippocampal slices were examined using extracellular and whole-cell patch-clamp recording techniques. The GABAA receptor antagonist picrotoxin (50 microM) was present in the bath in all experiments. 2. Histamine (0.7-70 microM) reversibly depressed field excitatory postsynaptic potentials (fEPSPs) or excitatory postsynaptic currents (EPSCs) recorded intracellularly by up to 30%. The presynaptic fibre volley and EPSC reversal potential were unaffected by histamine, as were responses following pressure ejection of the glutamate receptor agonist S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA) into the slice. 3. Histamine (7 microM) depressed equally the AMPA and N-methyl-D-aspartate (NMDA) components of the dual-component EPSC, recorded at -40 mV. 4. In addition to depressing synaptic transmission, histamine also reduced the magnitude of paired-pulse depression (PPD; 40 ms interpulse interval) of the medial perforant path EPSC. 5. Histamine depressed medial perforant path EPSCs more strongly than lateral perforant path EPSCs. Paired-pulse facilitation (PPF; 40 ms interpulse interval) in the lateral perforant path was enhanced by histamine. 6. The effects of histamine on synaptic transmission and PPD were mimicked by the selective H3 receptor agonist R-alpha-methylhistamine (0.1-10 microM) but not by the selective H2 receptor agonist dimaprit (10 microM). Similarly, the H3 receptor antagonist thioperamide (10 microM) blocked the effect of histamine whereas the H1 antagonist mepyramine (1 microM) and the H2 receptor antagonist cimetidine (50 microM) were ineffective. 7. Histamine actions on synaptic transmission and PPD were not occluded by application of the metabotropic glutamate agonist L-2-amino-4-phosphonobutyrate (AP4). 8. The results indicate that histamine depresses synaptic transmission in the dentate gyrus by binding to histamine H3 receptors located on perforant path terminals. The mechanism by which histamine depresses transmission is independent of that used by class III metabotropic glutamate receptors.
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