ArticleThe Journal of physiology1996
The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 123 citations in OpenAlex.
- Relation between Cerebrospinal Fluid Catecholamines and Vascular Risk Factors, Thyroid Function and Vitamins in Healthy Individuals and Patients with Neurodegenerative Diseases.Current Alzheimer research · 2026Observational
- Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes.iScience · 2024Article
- Comparing prophylactic effect of exercise and metformin on cognitive brain functions in rats with type 3 diabetes mellitus.Archives of medical science : AMS · 2024Article
- Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats.Diabetologia · 2019Article
- Article
- Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus.Experimental brain research · 2017Article
- Microfabrication and in Vivo Performance of a Microdialysis Probe with Embedded Membrane.Analytical chemistry · 2016Article
- Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus.Neurochemical research · 2015Review
- Is L-lactate a novel signaling molecule in the brain?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Review
- EEG-NIRS based assessment of neurovascular coupling during anodal transcranial direct current stimulation--a stroke case series.Journal of medical systems · 2015Article
- Diffusion of D-glucose measured in the cytosol of a single astrocyte.Cellular and molecular life sciences : CMLS · 2013Article
- Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II.The Journal of physiology · 2012Article
- Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation.ASN neuro · 2012Review
- Article
- Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.European journal of pharmacology · 2010Article
- Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans.The Journal of physiology · 2008Article
- Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma.Intensive care medicine · 2003Article
- Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Review
- An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Extracellular glucose turnover in the striatum of unanaesthetized rats measured by quantitative microdialysis.The Journal of physiology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. This study is concerned with the supply of metabolic substrates for neuronal metabolism. Experiments were carried out to investigate whether mechanisms demonstrated in cultured astrocytes also occurred in vivo; these were cAMP-mediated breakdown of glycogen and glutamate uptake-stimulated release of lactate. 2. In vivo microdialysis was used in freely moving rats. Lactate and glucose in the dialysate were assayed using enzyme-based on-line assays. Drugs were given locally through the dialysis probe. Regional cerebral blood flow was measured using the hydrogen clearance method. 3. There was an increase in dialysate glucose in response to the beta-adrenoceptor agonist isoprenaline and to 8-bromo-cAMP, an analogue of cAMP, the second messenger of beta-adrenoceptor stimulation. The effect of isoprenaline was blocked by the antagonist propranolol. Isoprenaline had no effect on dialysate lactate, which was increased by the glutamate uptake blocker beta-D,L-threohydroxyaspartate (THA). 4. Physiological stimulation of neuronal activity produced an increase in both lactate and glucose. The increase in lactate was depressed in the presence of THA but was unaffected by propranolol. The increase in glucose was blocked by propranolol. Regional cerebral blood flow was increased by physiological stimulation but was unaffected by propranolol. 5. These results demonstrate that physiologically stimulated increases in glucose and lactate in the brain are mediated by different mechanisms.
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Registered trials
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