ArticleThe Journal of cell biology1996
Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 72 citations in OpenAlex.
- Telomeres are shorter in wild Saccharomyces cerevisiae isolates than in domesticated ones.Genetics · 2023Article
- Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity.Journal of fungi (Basel, Switzerland) · 2022Review
- Bring It to an End: Does Telomeres Size Matter?Cells · 2019Review
- Article
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast.The Journal of biological chemistry · 2013Article
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- Review
- Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization.The EMBO journal · 2011Article
- Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast.The Journal of cell biology · 2011Article
- Spt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae.Eukaryotic cell · 2011Article
- Proteomic Evaluation of Cellular Responses of Saccharomyces cerevisiae to Formic Acid Stress.Mycobiology · 2010Article
- The budding yeast nucleus.Cold Spring Harbor perspectives in biology · 2010Review
- Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.PLoS genetics · 2010Article
- Developmentally regulated MAPK pathways modulate heterochromatin in Saccharomyces cerevisiae.Nucleic acids research · 2009Article
- The glucanosyltransferase Gas1 functions in transcriptional silencing.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.Genome research · 2009Article
- Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interaction.PLoS genetics · 2008Article
- Stochastic and regulatory role of chromatin silencing in genomic response to environmental changes.PloS one · 2008Article
- Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During cell division and growth, the nucleus and chromosomes are remodeled for DNA replication and cell type-specific transcriptional control. The yeast silencing protein Sir3p functions in both chromosome structure and in transcriptional regulation. Specifically, Sir3p is critical for the maintenance of telomere structure and for transcriptional repression at both the silent mating-type loci and telomeres. We demonstrate that Sir3p becomes hyperphosphorylated in response to mating pheromone, heat shock, and starvation. Cells exposed to pheromone arrest in G1 of the cell cycle, yet G1 arrest is neither necessary nor sufficient for pheromone-induced Sir3p hyperphosphorylation. Rather, hyperphosphorylation of Sir3p requires the mitogen-activated protein (MAP) kinase pathway genes STE11, STE7, FUS3/KSS1, and STE12, indicating that an intact signal transduction pathway is crucial for this Sir3p phosphorylation event. Constitutive activation of the pheromone-response MAP kinase cascade in an STE11-4 strain leads to hyperphosphorylation of Sir3p and increased Sir3p-dependent transcriptional silencing at telomeres. Regulated phosphorylation of Sir3p may thus be a mechanistically significant means for modulating silencing. Together, these observations suggest a novel role for MAP kinase signal transduction in coordinating chromatin structure and nuclear organization for transcriptional silencing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.