ArticleThe American journal of pathology1996
Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 88 citations in OpenAlex.
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- Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells.Gene regulation and systems biology · 2014Article
- Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer.Cancer metastasis reviews · 2009Review
- A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2009Review
- The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.Oncogene · 2008Article
- cDNA array analysis for prediction of hepatic metastasis of colorectal carcinoma.Surgery today · 2006Article
- Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches.Annals of surgery · 2003Review
- Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis.The American journal of pathology · 2003Article
- Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population.Nature genetics · 2003Article
- Redifferentiation and ZO-1 reexpression in liver-metastasized colorectal cancer: possible association with epidermal growth factor receptor-induced tyrosine phosphorylation of ZO-1.Cancer science · 2003Article
- Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma.Japanese journal of cancer research : Gann · 2002Article
- Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma.The American journal of pathology · 2001Article
- Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer.The American journal of pathology · 2000Article
- Cell surface molecules and their prognostic values in assessing colorectal carcinomas.Annals of surgery · 2000Review
- In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice.Neoplasia (New York, N.Y.) · 1999Article
- Tumour markers of prognosis in colorectal cancer.British journal of cancer · 1999Article
- In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions.Japanese journal of cancer research : Gann · 1998Article
- Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique.The American journal of pathology · 1997Article
- Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice.Neoplasia (New York, N.Y.)Article
- Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha.Neoplasia (New York, N.Y.)Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
We examined the expression level of several genes that regulate different steps of metastasis in formalin-fixed, paraffin-embedded archival specimens of primary human colon carcinomas from patients with at least 5 years of follow-up. The expression of epidermal growth factor receptor, basic fibroblast growth factor, type IV collagenase, E-cadherin, and multidrug resistance (mdr-1) was examined by a colorimetric in situ mRNA hybridization technique concentrating on reactivity at the periphery of the neoplasms. The in situ hybridization technique revealed inter- and intratumor heterogeneity for expression of the metastasis-related genes. The expression of basic fibroblast growth factor, collagenase type IV, epidermal growth factor receptor, and mdr-1 mRNA was higher in Dukes's stage D than in Dukes' stage B tumors. Among the 22 Dukes' stage B neoplasms, 5 specimens exhibited a high expression level of epidermal growth factor receptor, basic fibroblast growth factor, and collagenase type IV. Clinical outcome data (5-year follow-up) revealed that all 5 patients with Dukes' stage B tumors developed distant metastasis (recurrent disease), whereas the other 17 patients with Dukes' stage B tumors expressing low levels of the metastasis-related genes were disease-free. Multivariate analysis identified high levels of expression of collagenase type IV and low levels of expression of E-cadherin as independent factors significantly associated with metastasis or recurrent disease. More specifically, metastatic or recurrent disease was associated with a high ratio (> 1.35) of expression of collagenase type IV to E-cadherin (specificity of 95%). Collectively, the data show that multiparametric in situ hybridization analysis for several metastasis-related genes may predict the metastatic potential, and hence the clinical outcome, of individual lymph-node-negative human colon cancers.
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8909244PMC1865274W1714545534What OpenQuestion holds
Registered trials
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