ArticleEuropean archives of psychiatry and clinical neuroscience1996
A search for association between schizophrenia and dopamine-related alleles.
Article in European archives of psychiatry and clinical neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Investigating the association between commonJournal of genetics · 2021Pooled it
- Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia.Human genetics · 2006Pooled it
- A meta-analysis of data associatingNeuropsychiatric disease and treatment · 2018Article
- The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.Journal of physiological anthropology · 2017Review
- Associations between dopamine D2 receptor gene polymorphisms and schizophrenia risk: a PRISMA compliant meta-analysis.Neuropsychiatric disease and treatment · 2016Article
- Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra.Frontiers in psychiatry · 2012Article
- The dopamine D4 receptor: biochemical and signalling properties.Cellular and molecular life sciences : CMLS · 2010Review
- Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia.European journal of human genetics : EJHG · 2009Article
- Comments on the paper by D. Li and L. He: meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia.Human genetics · 2007Article
- Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics.Journal of human genetics · 2007Article
- The CCK-A receptor gene possibly associated with positive symptoms of schizophrenia.Molecular psychiatry · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparisons. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizophrenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.
Indexed as
Identifiers
8908411What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.