ArticleActa diabetologica1996
Elevated triglyceride-rich lipoproteins in diabetes. A study of apolipoprotein B-48.
Article in Acta diabetologica, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 86 citations in OpenAlex.
- Effect of sitagliptin on energy metabolism and brown adipose tissue in overweight individuals with prediabetes: a randomised placebo-controlled trial.Diabetologia · 2018Trial
- Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids.Diabetes · 2010Trial
- Comparison of diets high in monounsaturated versus polyunsaturated fatty acid on postprandial lipoproteins in diabetes.Irish journal of medical scienceTrial
- Intestinal lipid absorption and transport in type 2 diabetes.Diabetologia · 2022Review
- Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain.Advances in nutrition (Bethesda, Md.) · 2020Review
- Postprandial dyslipidemia in insulin resistant states in adolescent populations.Journal of biomedical research · 2020Article
- Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial).Journal of atherosclerosis and thrombosis · 2018Article
- Insights from human congenital disorders of intestinal lipid metabolism.Journal of lipid research · 2015Review
- ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- The efficacy of Ezetimibe added to ongoing Fibrate-Statin therapy on postprandial lipid profile in the patients with type 2 Diabetes mellitus.Journal of diabetes and metabolic disorders · 2013Article
- The chylomicron: relationship to atherosclerosis.International journal of vascular medicine · 2012Article
- Consumption of low doses of fat prevents the postprandial rise in chylomicron particle concentration and remnant accumulation in healthy normolipidaemic males.Journal of nutritional science · 2012Article
- Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans.Diabetes · 2011Article
- Jejunal wall triglyceride concentration of morbidly obese persons is lower in those with type 2 diabetes mellitus.Journal of lipid research · 2010Article
- Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans.Circulation · 2008Article
- The effect of exercise on postprandial lipidemia in type 2 diabetic patients.European journal of applied physiology · 2008Article
- Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice.The Journal of clinical investigation · 2000Article
- Hyperglycaemia: the relation to dyslipidaemia and atherosclerosis.Irish journal of medical scienceReview
- Robert Graves Memorial Lecture. Diabetes and atherosclerosis--a gut review.Irish journal of medical scienceArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the intestine in cholesterol metabolism in human diabetes is unclear, although abnormalities have been demonstrated in cholesterol synthesis and absorption in diabetic animals. This study examines the relationship between fasting and post-prandial apolipoprotein B-48 in type 2 (non-insulin-dependent) diabetic and non-diabetic subjects. Eight type 2 diabetic patients and ten healthy non-diabetic control subjects were given a high-fat meal (1300 kcal), and the triglyceride-rich lipoprotein fraction was isolated by ultracentrifugation (d < 1.006 g/ml) from fasting and post-prandial plasma. Apolipoprotein B-48 and apo B-100 were separated on 4%-15% gradient gels and quantified by densitometric scanning with reference to a purified low-density lipoprotein (LDL) apo B-100 preparation. Diabetic patients had significantly higher concentrations of apo B-48 and apo B-100 in both the fasting (P < 0.05) and post-prandial (P < 0.001) triglyceride-rich lipoprotein samples compared with non-diabetic subjects. The diabetic patients also exhibited a significantly different post-prandial profile for apo B-48 and apo B-100, with a prolonged increase and a later post-prandial peak, than the non-diabetic subjects (P < 0.01). These results suggest that the raised fasting triglyceride-rich lipoproteins, often found in diabetes, are associated with apo B-48 and may be derived from increased intestinal chylomicron production. The post-prandial pattern suggests an abnormality in intestinal production as well as hepatic clearance of apo B-48 in type 2 diabetes.
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