ArticleJournal of clinical microbiology1996
Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.
Article in Journal of clinical microbiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 84 citations in OpenAlex.
- Curiouser and curiouser: understanding the intersection of inter- and intra-specific diversity during theInfection and immunity · 2026Review
- Recent Progress in Lyme Disease and Remaining Challenges.Frontiers in medicine · 2021Review
- Genotyping and Quantifying Lyme Pathogen Strains by Deep Sequencing of the Outer Surface Protein C (Journal of clinical microbiology · 2018Article
- Amblyomma americanum (Acari: Ixodidae) Ticks Are Not Vectors of the Lyme Disease Agent, Borrelia burgdorferi (Spirocheatales: Spirochaetaceae): A Review of the Evidence.Journal of medical entomology · 2018Review
- Infection history of the blood-meal host dictates pathogenic potential of the Lyme disease spirochete within the feeding tick vector.PLoS pathogens · 2018Article
- Multiple independent transmission cycles of a tick-borne pathogen within a local host community.Scientific reports · 2016Article
- Role of the VlsE Lipoprotein in Immune Avoidance by the Lyme Disease SpirocheteForum on immunopathological diseases and therapeutics · 2016Article
- Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.PloS one · 2015Article
- Bacterial heterogeneity is a requirement for host superinfection by the Lyme disease spirochete.Infection and immunity · 2014Article
- A seventeen-year epidemiological surveillance study of Borrelia burgdorferi infections in two provinces of northern Spain.International journal of environmental research and public health · 2014Article
- Divergence of Borrelia burgdorferi sensu lato spirochetes could be driven by the host: diversity of Borrelia strains isolated from ticks feeding on a single bird.Parasites & vectors · 2014Article
- Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing.Infection and immunity · 2013Article
- Multilocus sequence typing of Borrelia burgdorferi suggests existence of lineages with differential pathogenic properties in humans.PloS one · 2013Article
- Differentiation of reinfection from relapse in recurrent Lyme disease.The New England journal of medicine · 2012Article
- Evolution of northeastern and midwestern Borrelia burgdorferi, United States.Emerging infectious diseases · 2010Article
- Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe.PloS one · 2010Article
- Detection of Borrelia burgdorferi DNA in lizards from Southern Maryland.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2007Article
- Genetic diversity of Borrelia burgdorferi sensu stricto in Peromyscus leucopus, the primary reservoir of Lyme disease in a region of endemicity in southern Maryland.Applied and environmental microbiology · 2006Article
- Mammal diversity and infection prevalence in the maintenance of enzootic Borrelia burgdorferi along the western Coastal Plains of Maryland.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2006Article
- Borrelia burgdorferi ospC heterogeneity among human and murine isolates from a defined region of northern Maryland and southern Pennsylvania: lack of correlation with invasive and noninvasive genotypes.Journal of clinical microbiology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The genetic heterogeneity of the spirochete Borrelia burgdorferi within single adult black-legged ticks from Shelter Island, N.Y., was determined by cold, single-strand conformation polymorphism (SSCP) analysis. The central region of the ospA gene of B. burgdorferi from infected ticks was amplified by nested PCR. Amplified product of the correct size was obtained from 20 to 45 ticks (44%). This is the fraction of ticks that is expected to be infected with B. burgdorferi. Four variant classes were determined by SSCP analysis. Eight ticks were infected with a single variant, nine ticks were infected with two variants, two ticks were infected with three variants, and one tick was infected with all four variants. DNA from each variant was sequenced. Five different sequences were found. The sequence of each variant was different from that of another variant by a single base. SSCP analysis could distinguish three of the four single-base changes found in the region.
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