ArticleJournal of clinical microbiology1996
Characterization of clinical isolates of Escherichia coli showing high levels of fluoroquinolone resistance.
Article in Journal of clinical microbiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Clinical isolates of Escherichia coli are resistant both to antibiotics and organotin compounds.Folia microbiologica · 2020Article
- Defining relatedness in studies of transmission of antimicrobial-resistant organisms: variability in definitions across studies and impact of different approaches on study conclusions.Infection control and hospital epidemiology · 2013Review
- The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Article
- Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.Antimicrobial agents and chemotherapy · 2001Article
- Risk factors for antibiotic-resistant Escherichia coli isolated from hospitalized patients with urinary tract infections: a prospective study.Journal of clinical microbiology · 2001Article
- In vivo increase in resistance to ciprofloxacin in Escherichia coli associated with deletion of the C-terminal part of MarR.Antimicrobial agents and chemotherapy · 2000Article
- Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.Antimicrobial agents and chemotherapy · 2000Article
- Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli.Antimicrobial agents and chemotherapy · 1999Article
- In vitro activities of cephalosporins and quinolones against Escherichia coli strains isolated from diarrheic dairy calves.Antimicrobial agents and chemotherapy · 1999Article
- Community acquired infections and bacterial resistance.BMJ (Clinical research ed.) · 1998Review
- Development of a rapid assay for detecting gyrA mutations in Escherichia coli and determination of incidence of gyrA mutations in clinical strains isolated from patients with complicated urinary tract infections.Journal of clinical microbiology · 1997Article
- A nosocomial outbreak due to Enterobacter cloacae strains with the E. hormaechei genotype in patients treated with fluoroquinolones.Journal of clinical microbiology · 1997Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the years 1992 to 1994, an increase in fluoroquinolone-resistant Escherichia coli was observed at the Medical Center of the Technical University in Munich, Germany. Nineteen strains were collected and were thus available for further analysis. Pulsed-field gel electrophoresis showed clonal diversity in all but two strains. The majority of the patients from whom the strains were isolated had been previously treated with fluoroquinolones. Quinolone resistance was associated with mutations of the quinolone resistance-determining region of the gyrA gene in all cases. Direct sequencing of gyrA PCR amplification products revealed a mutation in codon 83 of the gyrA gene. In some instances the Ser-83-->Leu mutation was accompanied by an Asp-87-->Asn or Asp-87-->Gly mutation. Furthermore, the strains exhibited two different genotypes: in almost half of the fluoroquinolone-resistant E. coli strains as well as in the fluoroquinolone-susceptible E. coli reference strains ATCC 25922 and 35218, silent mutations were detected at bases 255, 273, 300, and 333. Although fluoroquinolones solved major problems in antimicrobial chemotherapy, in certain departments of our hospital the number of resistant E. coli isolates has become so high that susceptibility to fluoroquinolones can no longer be taken for granted.
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