ArticleMammalian genome : official journal of the International Mammalian Genome Society1996
Rapid evolution of human pseudoautosomal genes and their mouse homologs.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- A strategic research alliance: Turner syndrome and sex differences.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.Biochimica et biophysica acta · 2016Article
- SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution.Genome biology and evolution · 2015Article
- Abnormal pairing of X and Y sex chromosomes during meiosis I in interspecific hybrids of Phodopus campbelli and P. sungorus.Scientific reports · 2015Article
- Recombination in the human Pseudoautosomal region PAR1.PLoS genetics · 2014Article
- The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors.BMC cancer · 2012Article
- The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome.BMC genomics · 2008Article
- Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece.Developmental biology · 2007Article
- Creation of non-human primate neurogenetic disease models by gene targeting and nuclear transfer.Reproductive biology and endocrinology : RB&E · 2004Review
- Article
- Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution.Genome research · 2001Article
- A short pseudoautosomal region in laboratory mice.Genome research · 2001Article
- The Human Y Chromosome: The Biological Role of a "Functional Wasteland"Journal of biomedicine & biotechnology · 2001Article
- Novel gene conversion between X-Y homologues located in the nonrecombining region of the Y chromosome in Felidae (Mammalia).Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The Ant1 gene maps near Klk3 on proximal mouse chromosome 8.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative studies of genes in the pseudoautosomal region (PAR) of human and mouse sex chromosomes have thus far been very limited. The only comparisons that can presently be made indicate that the PARs of humans and mice are not identical in terms of gene content. Here we describe additional comparative studies of human pseudoautosomal genes and their mouse homologs. Using a somatic cell hybrid mapping panel, we have assigned the mouse homolog of the human pseudoautosomal interleukin 3 receptor alpha subunit (IL3RA) gene to mouse Chromosome (Chr) 14. Attempts to clone the mouse homolog of the human pseudoautosomal adenine nucleotide translocase-3 (ANT3) gene resulted in the isolation of the murine homologs of the human ANT1 and ANT2 genes. The mouse Ant1 and Ant2 genes are very similar in sequence to their human homologs, and we have mapped them to mouse Chromosomes (Chrs) (8 and X respectively) that exhibit conserved synteny with the chromosomes on which the human genes are located. In contrast, the homolog of ANT3 appears to be either very divergent or absent from the mouse genome. Southern blot analysis of DNA from a variety of mammalian species shows restricted conservation of human pseudoautosomal genes, a trend that also applies to the two cloned mouse homologs of these genes and to neighboring human genes in distal Xp22.3. Our observations combined with those of other workers lead us to propose a model for the evolution of the PAR that includes both rapid sequence evolution and the incremental reduction in size of the region during mammalian evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.