ArticleProceedings of the National Academy of Sciences of the United States of America1996
A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 82 citations in OpenAlex.
- Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets.Current neuropharmacology · 2024Review
- Astroglial Alterations in the Hippocampus of Rats Submitted to a Single Trans-Cranial Direct Current Stimulation Trial.Neurochemical research · 2023Article
- Perinatal stress, brain inflammation and risk of autism-review and proposal.BMC pediatrics · 2012Review
- Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.Gastroenterology · 2011Article
- Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells.The Journal of biological chemistry · 2011Article
- Neurotensin is increased in serum of young children with autistic disorder.Journal of neuroinflammation · 2010Article
- Neuropeptides, mesenteric fat, and intestinal inflammation.Annals of the New York Academy of Sciences · 2008Review
- Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells.International journal of cancer · 2007Article
- Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A comparative study of the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat.Digestive diseases and sciences · 2004Article
- The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammation.Digestive diseases and sciences · 2004Article
- Effect of psychogenic stress on gastrointestinal function.Journal of physiology and biochemistry · 2000Review
- Neurotensin is a proinflammatory neuropeptide in colonic inflammation.The Journal of clinical investigation · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported that short-term immobilization stress of rats causes increased colonic mucin release, goblet cell depletion, prostaglandin E2 secretion, and colonic mast cell activation, as well as increased colonic motility. The purpose of this study was to investigate whether neurotensin (NT), a peptide expressed in both brain and digestive tract, participates in these responses. Rats were pretreated with SR 48692 (1 mg/kg, i.p.), an NT antagonist, 15 min before immobilization (30 min). The administration of the antagonist significantly inhibited stress-mediated secretion of colonic mucin, prostaglandin E2, and a product of rat mast cells, rat mast cell protease II (P < 0.05), but did not alter the increase in fecal pellet output caused by immobilization stress. Immobilization stress also resulted in a quantifiable decrease in the abundance of NT receptor mRNA in rat colon compared with that in colonic tissues from nonimmobilized rats as measured by densitometric analysis of in situ hybridization studies (P < 0.03). We conclude that the peptide NT is involved in colonic goblet cell release and mucosal mast cell activation after immobilization stress.
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Registered trials
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