ArticleProceedings of the National Academy of Sciences of the United States of America1996
Amphipathic domains in the C terminus of the transmembrane protein (gp41) permeabilize HIV-1 virions: a molecular mechanism underlying natural endogenous reverse transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Characterization of full-length and cytoplasmic tail-truncated envelope glycoproteins incorporated into human immunodeficiency virus (HIV-1) virions and virus-like particles.Journal of virology · 2025Article
- A novel aptamer-based dNTP assay reveals that intact HIV virions are highly stable and do not contain enough dNTPs to support DNA synthesis.Journal of virology · 2025Article
- The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription.PLoS pathogens · 2024Article
- The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription.bioRxiv : the preprint server for biology · 2023Article
- Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity.Molecules (Basel, Switzerland) · 2015Article
- APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10.The Journal of biological chemistry · 2012Article
- Membrane topology analysis of HIV-1 envelope glycoprotein gp41.Retrovirology · 2010Article
- Roles of Gag and NCp7 in facilitating tRNA(Lys)(3) Annealing to viral RNA in human immunodeficiency virus type 1.Journal of virology · 2009Article
- Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.Nucleic acids research · 2008Article
- Cell factors stimulate human immunodeficiency virus type 1 reverse transcription in vitro.Journal of virology · 2008Article
- Isolated HIV-1 core is active for reverse transcription.Retrovirology · 2007Article
- Development of a new methodology for screening of human immunodeficiency virus type 1 microbicides based on real-time PCR quantification.Antimicrobial agents and chemotherapy · 2007Article
- In vitro synthesis of long DNA products in reactions with HIV-RT and nucleocapsid protein.Journal of molecular biology · 2007Article
- Inhibition of endogenous reverse transcription of human and nonhuman primate lentiviruses: potential for development of lentivirucides.Virology · 2006Article
- Article
- Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.Journal of virology · 2001Article
- Cellular membrane-binding ability of the C-terminal cytoplasmic domain of human immunodeficiency virus type 1 envelope transmembrane protein gp41.Journal of virology · 2001Article
- Inhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcription.Journal of virology · 2001Article
- The multimerization of human immunodeficiency virus type I Vif protein: a requirement for Vif function in the viral life cycle.The Journal of biological chemistry · 2001Article
- Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process.Journal of virology · 2000Article
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Authors and funding
5 authors.
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Abstract
Reverse transcription of HIV-1, without detergent or amphipathic peptide-induced permeability of the viral envelope, has been demonstrated to occur in the intact HIV-1 virion. In this report, we demonstrate that the amphipathic domains in the C terminus of the transmembrane glycoprotein (gp41) account for the natural permeability of the HIV-1 envelope to deoxyribonucleoside triphosphates, the substrates for DNA polymerization. In addition, nonphysiological deoxyribonucleoside triphosphates, such as 3'-azido-3'-deoxythymidine 5'-triphosphate and 3'-deoxythymidine 5'-triphosphate, can also penetrate the viral envelope, incorporate into, and irreversibly terminate reverse transcripts. As a result, viral infectivity is potently inhibited. Since the lentiviral envelope with these newly demonstrated characteristics can serve as a delivery pathway for anti-reverse transcription agents, we propose a unique strategy to prevent HIV-1 interand, possibly, intrahost transmission.
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