ArticleProceedings of the National Academy of Sciences of the United States of America1996
Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed.
- Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens,Current clinical microbiology reports · 2023Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- OralJournal of oral microbiology · 2020Article
- Review
- Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway.PLoS biology · 2019Article
- Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Parasex Generates Phenotypic DiversityGenetics · 2017Article
- Candida albicans cell-type switching and functional plasticity in the mammalian host.Nature reviews. Microbiology · 2017Review
- Population Genetics of Hirsutella rhossiliensis, a Dominant Parasite of Cyst Nematode Juveniles on a Continental Scale.Applied and environmental microbiology · 2016Article
- The frequency of sex in fungi.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Article
- Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans.Current genetics · 2016Review
- Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity.Current opinion in microbiology · 2015Review
- Article
- Clonal reproduction in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Genetic differentiation and recombination among geographic populations of the fungal pathogen Colletotrichum truncatum from chili peppers in China.Evolutionary applications · 2015Article
- Evolutionary Perspectives on Human Fungal Pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Unisexual reproduction reverses Muller's ratchet.Genetics · 2014Article
- The strictly aerobic yeast Yarrowia lipolytica tolerates loss of a mitochondrial DNA-packaging protein.Eukaryotic cell · 2014Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
The life history of Candida albicans presents an enigma: this species is thought to be exclusively asexual, yet strains show extensive phenotypic variation. To address the population genetics of C. albicans, we developed a genetic typing method for codominant single-locus markers by screening randomly amplified DNA for single-strand conformation polymorphisms. DNA fragments amplified by arbitrary primers were initially screened for single-strand conformation polymorphisms and later sequenced using locus-specific primers. A total of 12 single base mutations and insertions were detected from six out of eight PCR fragments. Patterns of sequence-level polymorphism observed for individual strains detected considerable heterozygosity at the DNA sequence level, supporting the view that most C. albicans strains are diploid. Population genetic analyses of 52 natural isolates from Duke University Medical Center provide evidence for both clonality and recombination in C. albicans. Evidence for clonality is supported by the presence of several overrepresented genotypes, as well as by deviation of genotypic frequencies from random (Hardy-Weinberg) expectations. However, tests for nonrandom association of alleles across loci reveal less evidence for linkage disequilibrium than expected for strictly clonal populations. Although C. albicans populations are primarily clonal, evidence for recombination suggests that sexual reproduction or some other form of genetic exchange occurs in this species.
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