ArticleProceedings of the National Academy of Sciences of the United States of America1996
Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 167 citations in OpenAlex.
- Animal models for transplant immunology: bridging bench to bedside.Clinical transplantation and research · 2024Review
- Immune-checkpoint expression in antigen-presenting cells (APCs) of cytomegaloviruses infection after transplantation: as a diagnostic biomarker.Archives of microbiology · 2023Review
- Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival.Journal of clinical medicine · 2020Review
- Impact of infection on transplantation tolerance.Immunological reviews · 2019Review
- Ex Vivo Major Histocompatibility Complex I Knockdown Prolongs Rejection-free Allograft Survival.Plastic and reconstructive surgery. Global open · 2018Article
- Update on the treatment of focal segmental glomerulosclerosis in renal transplantation.World journal of transplantation · 2016Review
- Update on CD40 and CD154 blockade in transplant models.Immunotherapy · 2015Review
- Experimental rat models of chronic allograft nephropathy: a review.International journal of nephrology and renovascular disease · 2014Review
- T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance.International journal of organ transplantation medicine · 2014Review
- T-cell costimulatory blockade in organ transplantation.Cold Spring Harbor perspectives in medicine · 2013Review
- Costimulation blockade: current perspectives and implications for therapy.Transplantation · 2013Review
- The nature of activatory and tolerogenic dendritic cell-derived signal II.Frontiers in immunology · 2013Article
- Recipient cytotoxic T lymphocyte antigen 4 +49 single-nucleotide polymorphism is not associated with acute rejection after liver transplantation in Chinese population.International journal of medical sciences · 2013Article
- CTLA4-Ig prevents alloantibody production and BMT rejection in response to platelet transfusions in mice.Transfusion · 2012Article
- The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Review
- T-cell activation and transplantation tolerance.Transplantation reviews (Orlando, Fla.) · 2012Review
- CD28 family and chronic rejection: "to belatacept...And beyond!".Journal of transplantation · 2012Article
- The role of coinhibitory signaling pathways in transplantation and tolerance.Frontiers in immunology · 2012Article
- Article
- Costimulatory pathways in transplantation.Seminars in immunology · 2011Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting cells, prevents rejection and induces tolerance in experimental acute allograft rejection models. We tested the effect of CTLA4Ig therapy on the process of chronic renal allograft rejection using an established experimental transplantation model. F344 kidneys were transplanted orthotopically into bilaterally nephrectomized LEW recipients. Control animals received low dose cyclosporine for 10 days posttransplantation. Administration of a single injection of CTLA4Ig on day 2 posttransplant alone or in addition to the low dose cyclosporine protocol resulted in improvement of long-term graft survival as compared with controls. More importantly, control recipients which received cyclosporine only developed progressive proteinuria by 8-12 weeks, and morphological evidence of chronic rejection by 16-24 weeks, including widespread transplant arteriosclerosis and focal and segmental glomerulosclerosis, while animals treated with CTLA4Ig alone or in addition to cyclosporine did not. Competitive reverse transcriptase-PCR and immunohistological analysis of allografts at 8, 16, and 24 weeks showed attenuation of lymphocyte and macrophage infiltration and activation in the CTLA4Ig-treated animals, as compared with cyclosporine-alone treated controls. These data confirm that early blockade of the CD28-B7 T-cell costimulatory pathway prevents later development and evolution of chronic renal allograft rejection. Our results indicate that T-cell recognition of alloantigen is a central event in initiating the process of chronic rejection, and that strategies targeted at blocking T-cell costimulation may prove to be a valuable clinical approach to preventing development of the process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.