ArticleProceedings of the National Academy of Sciences of the United States of America1996
NF-kappa B homodimer binding within the HIV-1 initiator region and interactions with TFII-I.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Targeting Viral Transcription for HIV Cure Strategies.Microorganisms · 2024Review
- Host Restriction Factors Modulating HIV Latency and Replication in Macrophages.International journal of molecular sciences · 2022Review
- Review
- Distinctive variation in the U3R region of the 5' Long Terminal Repeat from diverse HIV-1 strains.PloS one · 2018Article
- Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci.Journal of cellular biochemistry · 2018Article
- A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity.PloS one · 2015Article
- A stimulation-dependent alternate core promoter links lymphotoxin α expression with TGF-β1 and fibroblast growth factor-7 signaling in primary human T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB.Virology · 2012Article
- Review
- Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.Retrovirology · 2009Review
- IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I.European journal of immunology · 2009Article
- Regulation of HIV-1 latency by T-cell activation.Cytokine · 2007Review
- Article
- Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.Protein science : a publication of the Protein Society · 2004Article
- Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription.Molecular and cellular biology · 2001Article
- The Rous sarcoma virus long terminal repeat promoter is regulated by TFII-I.Journal of virology · 2000Article
- Isolation and characterization of BEN, a member of the TFII-I family of DNA-binding proteins containing distinct helix-loop-helix domains.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.Nucleic acids research · 2000Review
- Regulation of HIV-1 transcription.Gene expression · 1999Review
- Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 Tax protein is through cooperation of NF-kappaB and Tat.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We show that the binding of Rel p50 and p52 homodimers at sites within the transcriptional initiation region of HIV-1 provides for their ability to interact with other proteins that bind the initiator. The binding of one such protein, the initiator protein TFII-I, to the initiation region of HIV-1 is augmented in the presence of Rel p50 and Rel p52 homodimers. Consistent with this, in vitro Rel homodimers potentiate HIV-1 transcription in a manner dependent upon TFII-I. The findings suggest that Rel dimers may regulate HIV-1 transcription in two ways. First, through binding at the kappa B enhancer sites at (-104 to -80), NF-kappa B p50:p65 participates in classical transcriptional activation. Second, Rel dimers such as p50 or p52 might bind at initiator sequences to regulate the de novo binding of components of certain preinitiation complexes. These findings, and the existence of Rel binding sites at the initiators of other genes, suggest roles for Rel proteins in early events determining transcriptional control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.