ArticleProceedings of the National Academy of Sciences of the United States of America1996
Combinations of closely situated cis-acting elements determine tissue-specific patterns and anterior extent of early Hoxc8 expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Whole-transcriptome analysis reveals key transcriptional and noncoding RNA regulators of skeletal muscle satellite cell differentiation in quail.Poultry science · 2026Article
- Identification of a Chondrocyte-Specific Enhancer in theJournal of developmental biology · 2024Article
- HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.Molecular cancer · 2017Article
- Article
- Patterns and evolution of ACGT repeat cis-element landscape across four plant genomes.BMC genomics · 2013Article
- Homeobox C9 is not potentially related to congenital heart disease in Chinese patients.Genetic testing and molecular biomarkers · 2012Article
- Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
- Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.Molecules and cells · 2011Article
- Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The identification of Hoxc8 target genes.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Phylogenetic analysis of the mammalian Hoxc8 non-coding region.Journal of structural and functional genomics · 2003Article
- The caudal homeodomain protein activates Drosophila E2F gene expression.Nucleic acids research · 2002Article
- Homeobox genes in gut development.Gut · 2002Review
- Isolation and characterization of BEN, a member of the TFII-I family of DNA-binding proteins containing distinct helix-loop-helix domains.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Modification of expression and cis-regulation of Hoxc8 in the evolution of diverged axial morphology.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.The EMBO journal · 1997Article
- Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific.Nucleic acids research · 1997Article
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2 authors.
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Abstract
We have used a transgene mutation approach to study how expression domains of Hoxc8 are established during mouse embryogenesis. A cis-regulatory region located 3 kb upstream from the Hoxc8 translational start site directs the early phase of expression. Four elements, termed A, B, C, and D, were previously shown to direct expression to the neural tube. Here we report that a fifth element, E, located immediately downstream of D directs expression to mesoderm in combination with the other four elements. These elements are interdependent and partially redundant. Different combinations of elements determine expression in different posterior regions of the embryo. Neural tube expression is determined minimally by ABC, ABD, or ACD; somite expression by ACDE; and lateral plate mesoderm expression by DE. Neural tube and lateral plate mesoderm enhancers can be separated, but independent somite expression has not been achieved. Furthermore, mutations within these elements result in posteriorization of the reporter gene expression. Thus, the anterior extent of expression is determined by the combined action of these elements. We propose that the early phase of Hoxc8 expression is directed by two separate mechanisms: one that determines tissue specificity and another that determines anterior extent of expression.
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