ArticleProceedings of the National Academy of Sciences of the United States of America1996
msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 94 citations in OpenAlex.
- Cited2 is a key regulator of placental development and plasticity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.Pigment cell & melanoma research · 2024Article
- Exploring the role of CITED transcriptional regulators in the control of macrophage polarization.Frontiers in immunology · 2024Review
- Roles and signaling pathways of CITED1 in tumors: overview and novel insights.The Journal of international medical research · 2024Review
- Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1.Journal of cell science · 2023Article
- Single-cell RNA-sequencing analysis of the ciliary epithelium and contiguous tissues in the mouse eye.Experimental eye research · 2021Article
- Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.Cell death & disease · 2018Article
- CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer.Oncology letters · 2018Article
- CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27.Cell & bioscience · 2018Article
- Divergence of Genes EncodingFrontiers in physiology · 2018Article
- The DNA methylation landscape of human melanoma.Genomics · 2015Article
- TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.Current biology : CB · 2015Article
- Article
- CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.Oncotarget · 2014Article
- Cited1 deficiency suppresses intestinal tumorigenesis.PLoS genetics · 2013Article
- Depigmenting effect of Kojic acid esters in hyperpigmented B16F1 melanoma cells.Journal of biomedicine & biotechnology · 2012Article
- Article
- Functional significance of SRJ domain mutations in CITED2.PloS one · 2012Article
- Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.Development (Cambridge, England) · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Messenger RNA transcripts of the highly pigmented murine melanoma B16-F1 cells were compared with those from their weakly pigmented derivative B16-F10 cells by differential display. A novel gene called msg1 (melanocyte-specific gene) was found to be expressed at high levels in B16-F1 cells but at low levels in B16-F10 cells. Expression of msg1 was undetectable in the amelanotic K1735 murine melanoma cells. The pigmented murine melanocyte cell line melan-a expressed msg1, as did pigmented primary cultures of murine and human melanocytes; however, seven amelanotic or very weakly pigmented human melanoma cell lines were negative. Transformation of murine melanocytes by transfection with v-Ha-ras or Ela was accompanied by depigmentation and led to complete loss of msg1 expression. The normal tissue distribution of msg1 mRNA transcripts in adult mice was confined to melanocytes and testis. Murine msg1 and human MSG1 genes encode a predicted protein of 27 kDa with 75% overall amino acid identity and 96% identity within the C-terminal acidic domain of 54 amino acids. This C-terminal domain was conserved with 76% amino acid identity in another protein product of a novel human gene, MRG1 (msg1-related gene), isolated from normal human melanocyte cDNA by 5'-rapid amplification of cDNA ends based on the homology to msg1. The msg1 protein was localized to the melanocyte nucleus by immunofluorescence cytochemistry. We conclude that msg1 encodes a nuclear protein, is melanocyte-specific, and appears to be lost in depigmented melanoma cells.
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