ArticleProceedings of the National Academy of Sciences of the United States of America1996
cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 79 citations in OpenAlex.
- Comparative Analysis of Testicular Transcriptional and Translational Landscapes in Yak and Cattle-Yak: Implications for Hybrid Male Sterility.Biomolecules · 2025Article
- Characterization of the promoter region of the murine Catsper2 gene.FEBS open bio · 2022Article
- cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Article
- Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.Development (Cambridge, England) · 2018Article
- Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- cAMP responsive element modulator: a critical regulator of cytokine production.Trends in molecular medicine · 2013Review
- A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme.Pharmacological reviews · 2013Review
- Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats.PloS one · 2013Article
- Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis.PloS one · 2012Article
- Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.BMC genomics · 2010Article
- Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells.Nucleic acids research · 2010Article
- Role of basic leucine zipper proteins in transcriptional regulation of the steroidogenic acute regulatory protein gene.Molecular and cellular endocrinology · 2009Review
- The CREM system in human spermatogenesis.Journal of endocrinological investigation · 2000Review
- A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids.Molecular and cellular biology · 1999Article
- The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell.The Biochemical journal · 1998Article
- Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme.The Journal of clinical investigation · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Testis angiotensin-converting enzyme (ACE) is a unique form of ACE, only produced by male germ cells, and results from a testis-specific promoter found within the ACE gene. We have investigated the role of cAMP-response element modulator (CREM)tau in testis ACE transcription. In gel shift experiments, testes nuclear proteins retard an oligonucleotide containing the cAMP-response element (CRE) found at position -55 in the testis ACE promoter. Anti-CREM antibody supershifts this complex. Competitive gel shift shows that recombinant CREM tau protein and testis nuclear proteins have a similar specificity of binding to the tests ACE CRE. Functional analysis using in vitro transcription and transfection studies also demonstrate that CREM tau protein is a transcriptional activator of the testis ACE promoter. Western blot analysis identifies CREM tau protein in the protein-DNA complex formed between nuclear proteins and the testis ACE CRE motif. This analysis also identified other CREM isoforms in the gel-shifted complex, which are thought to be CREM tau 1/2, CREM alpha/beta, and S-CREM. These data indicate that CREM tau isoforms play an important role as a positive regulator in the tissue-specific expression of testis ACE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.