ArticleProceedings of the National Academy of Sciences of the United States of America1996
Conserved promoter elements in the CYP6B gene family suggest common ancestry for cytochrome P450 monooxygenases mediating furanocoumarin detoxification.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 65 citations in OpenAlex.
- The ROS-FOXO pathway mediates broad-spectrum detoxification of acaricides in Tetranychus cinnabarinus.Communications biology · 2025Article
- The P450 genes of the cat flea,Current research in insect science · 2022Article
- High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated with cytochrome P450-mediated detoxification in a generalist arthropod pest.PLoS genetics · 2021Article
- The retardant effect of 2-Tridecanone, mediated by Cytochrome P450, on the Development of Cotton bollworm, Helicoverpa armigera.BMC genomics · 2016Article
- Gene amplification and microsatellite polymorphism underlie a recent insect host shift.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Molecular cloning and recombinant expression of cytochrome P450 CYP6B6 from Helicoverpa armigera in Escherichia coli.Molecular biology reports · 2013Article
- Ecological significance of induction of broad-substrate cytochrome P450s by natural and synthetic inducers in Helicoverpa zea.Journal of chemical ecology · 2009Article
- Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice.Toxicology and applied pharmacology · 2008Article
- Unusually divergent 4-coumarate:CoA-ligases from Ruta graveolens L.Plant molecular biology · 2008Article
- Dynamic regulation of Drosophila nuclear receptor activity in vivo.Development (Cambridge, England) · 2006Article
- Postgenomic chemical ecology: from genetic code to ecological interactions.Journal of chemical ecology · 2002Review
- The role of cytochrome P450 monooxygenases in plant-insect interactions.Plant physiology · 1996Review
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5 authors at 2 institutions in 1 country.
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Abstract
Despite the fact that Papilio glaucus and Papilio polyxenes share no single hostplant species, both species feed to varying extents on hostplants that contain furanocoumarins. P. glaucus contains two nearly identical genes, CYP6B4v2 and CYP6B5v1, and P. polyxenes contains two related genes, CYP6B1v3 and CYP6B3v2. Except for CYP6B3v2, the substrate specificity of which has not yet been defined, each of the encoded cytochrome P450 monooxygenases (P450s) metabolizes an array of linear furanocoumarins. All four genes are transcriptionally induced in larvae by exposure to the furanocoumarin xanthotoxin; several are also induced by other furanocoumarins. Comparisons of the organizational structures of these genes indicate that all have the same intron/exon arrangement. Sequences in the promoter regions of the P. glaucus CYP6B4v2/CYP6B5v1 genes and the P. polyxenes CYP6B3v2 gene are similar but not identical to the -146 to -97 region of CYP6B1v3 gene, which contains a xanthotoxin-responsive element (XRE-xan) important for basal and xanthotoxin-inducible transcription of CYP6B1v3. Complements of the xenobiotic-responsive element (XRE-AhR) in the dioxin-inducible human and rat CYP1A1 genes also exist in all four promoters, suggesting that these genes may be regulated by dioxin. Antioxidant-responsive elements (AREs) in mouse and rat glutathione S-transferase genes and the Barbie box element (Bar) in the bacterial CYP102 gene exist in the CYP6B1v3, CYP6B4v2, and CYP6B5v1 promoters. Similarities in the protein sequences, intron positions, and xanthotoxin- and xenobiotic-responsive promoter elements indicate that these insect CYP6B genes are derived from a common ancestral gene. Evolutionary comparisons between these P450 genes are the first available for a group of insect genes transcriptionally regulated by hostplant allelochemicals and provide insights into the process by which insects evolve specialized feeding habits.
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