ArticleMolecular medicine (Cambridge, Mass.)1996
Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene.
Article in Molecular medicine (Cambridge, Mass.), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 87 citations in OpenAlex.
- Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway.Oncology letters · 2021Article
- Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis.Hepatology (Baltimore, Md.) · 2020Observational
- Lack of hepatic stimulator substance expression promotes hepatocellular carcinoma metastasis partly through ERK-activated epithelial-mesenchymal transition.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease.The Biochemical journal · 2017Review
- The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.Pathology oncology research : POR · 2016Article
- Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.Gastroenterology · 2015Article
- Involvement of hepatic stimulator substance in the regulation of hepatoblast maturation into hepatocytes in vitro.Stem cells and development · 2014Article
- Adenoviral gene transfer of hepatic stimulator substance confers resistance against hepatic ischemia-reperfusion injury by improving mitochondrial function.Human gene therapy · 2013Article
- Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies.Molecular medicine (Cambridge, Mass.) · 2013Article
- Augmenter of liver regeneration.Fibrogenesis & tissue repair · 2012Article
- Increased hepatic apoptosis in high-fat diet-induced NASH in rats may be associated with downregulation of hepatic stimulator substance.Journal of molecular medicine (Berlin, Germany) · 2011Article
- From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways.World journal of gastrointestinal oncology · 2010Article
- Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells.Journal of cellular physiology · 2010Article
- Expression and localization of augmenter of liver regeneration in human muscle tissue.International journal of experimental pathology · 2009Article
- Genetic recombinant expression and characterization of human augmenter of liver regeneration.Digestive diseases and sciences · 2009Article
- Redox regulation of protein folding in the mitochondrial intermembrane space.Biochimica et biophysica acta · 2009Review
- Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes.Journal of hepatology · 2008Article
- Effect of heat and pH denaturation on the structure and conformation of recombinant human hepatic stimulator substance.The protein journal · 2007Article
- Insights on augmenter of liver regeneration cloning and function.World journal of gastroenterology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gene encoding the hepatotrophic factor Augmenter of Liver Regeneration (ALR) has recently been cloned in the rat. The availability of the mouse form of ALR would allow the analysis of the role of this factor in the physiology of liver and other organs, while the identification of the human homolog would allow the transfer of the great wealth of information that has been generated in animal models to clinically oriented pilot trials, and eventually the therapeutic application of this information. MATERIALS AND
methodsStandard molecular biology approaches have been used to determine the genomic structure of the ALR gene in the mouse, and to characterize the ALR transcript and its protein product. The human ALR cDNA was also isolated and the amino acid sequence of the human gene product deduced. The mapping of mouse and human ALR genes on mouse and human chromosomes was then completed.
resultsThe protein coding portion of the mouse ALR gene is comprised of three exons, the first containing the 5' untranslated sequence and the initial 18 bases after the ATG translation initiation codon, the second exon encompasses 198 bases, and the third exon contains the remaining portion of the protein coding sequence. Rat, mouse, and human ALR genes (and protein products) were found to be highly conserved and preferentially expressed in the testis and in the liver. The ALR gene maps to the mouse chromosome 17, in a region syntenic with human chromosome 16, where the T/t region has also been mapped.
conclusionsALR appears to be a protein with important physiologic properties, not exclusively limited to liver regeneration, with roles that are involved in the synthesis or stability of the nuclear and mitochondrial transcripts that are present in actively regenerating cells, particularly the germ cells of the testes.
Indexed as
Identifiers
8900538PMC2230030W1667518891What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.