ArticlePediatric nephrology (Berlin, Germany)1996
Long-term therapy with enalapril in patients with nephrotic-range proteinuria.
Article in Pediatric nephrology (Berlin, Germany), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis.Kidney international · 2011Trial
- Novel therapies for resistant focal segmental glomerulosclerosis (FONT) phase II clinical trial: study design.BMC nephrology · 2011Trial
- Enalapril in children with Alport syndrome.Pediatric nephrology (Berlin, Germany) · 2004Trial
- Enalapril dosage in steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Trial
- Antiproteinuric effects of enalapril and losartan: a pilot study.Pediatric nephrology (Berlin, Germany) · 2003Trial
- Outcomes of steroid-resistant nephrotic syndrome in children not treated with intensified immunosuppression.Pediatric nephrology (Berlin, Germany) · 2023Article
- Additive antiproteinuric effect of enalapril and losartan in children with hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2013Article
- Drugs controlling proteinuria of patients with Alport syndrome.World journal of pediatrics : WJP · 2009Article
- Translational mini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis.Clinical and experimental immunology · 2008Review
- Progression of chronic renal failure in children with dysplastic kidneys.Pediatric nephrology (Berlin, Germany) · 2007Article
- Therapeutic approach to FSGS in children.Pediatric nephrology (Berlin, Germany) · 2007Review
- Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Article
- Renoprotection by ACE inhibitors after severe hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of enalapril on urinary protein excretion and renal function was studied in six paediatric patients with various renal diseases causing nephroticrange proteinuria. In three younger children (aged 7-9 years) with steroid-resistant nephrotic syndrome, enalapril at a dose of 0.5 mg/kg per day given for 24 months yielded a temporary reduction of proteinuria in one child, a moderate and steady decrease in another and a complete disappearance of proteinuria in the third. Three adolescents, aged 17 years, took enalapril for 24 months at a dose of 20 mg/day. We observed no effect on proteiuria in one patient with Alport syndrome, a complete disappearance of urinary protein in one patient with membranoproliferative glomerulonephritis and a moderate decrease in the third patient who had idiopathic steroid-resistant nephrotic syndrome. Enalapril therapy resulted in an important reduction of proteinuria in two patients and a moderate decrease in three others. However this therapy was accompanied by a fall in glomerular filtration in all subjects, which was very marked in two patients. This fall in glomerular filtration may, however, simply reflect the natural course of the disease.
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