ArticleNeurochemical research1996
Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.
Article in Neurochemical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 103 citations in OpenAlex.
- Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer's disease: A comprehensive review.Heliyon · 2024Review
- Review
- Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory.Physiology & behavior · 2016Review
- Attenuation in rats of impairments of memory by scopolamine, a muscarinic receptor antagonist, by mecamylamine, a nicotinic receptor antagonist.Psychopharmacology · 2016Article
- Alzheimer's disease: Targeting the Cholinergic System.Current neuropharmacology · 2016Review
- Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders.Biochemical pharmacology · 2015Review
- Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning.Neurobiology of learning and memory · 2014Review
- Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants.Journal of neurochemistry · 2009Article
- The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum.Biochemical pharmacology · 2007Review
- Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.Brain research reviews · 2007Review
- In vivo neurochemical characterization of anatoxin-a evoked dopamine release from striatum.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- In vivo effects of the anatoxin-a on striatal dopamine release.Neurochemical research · 2006Article
- Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons.The Journal of physiology · 2000Article
- Pharmacological characterization of nicotine-induced acetylcholine release in the rat hippocampus in vivo: evidence for a permissive dopamine synapse.British journal of pharmacology · 1999Article
- Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurones show different agonist profiles.The Journal of physiology · 1999Article
- Nerve terminal currents induced by autoreception of acetylcholine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Functional contribution of the alpha7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones.The Journal of physiology · 1998Article
- Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline, (-)-Nicotine (0.1-10 microM) evoked a dose-dependent increase in [3H]ACh release; higher concentrations were less effective. Nicotine-evoked release was Ca(2+)-dependent, and blocked by the nicotinic antagonists dihydro-beta-erythroidine, mecamylamine, and pempidine. The alpha 7-selective antagonist methyllycaconitine did not inhibit nicotine-evoked release when tested at 1 microM, although at 10 microM some attenuation of the response was observed. Six agonists tested were equally efficacious in stimulating [3H]ACh release, as judged by the maximum responses, and gave the following EC50 values: (+/-)-epibatidine 0.12 microM; (+)-anatoxin-a 0.14 microM; (-)-nicotine 0.99 microM; (-)-cytisine 1.06 microM; ABT-418 2.6 microM; isoarecolone 43 microM. Each agonist generated a "bell-shaped" dose response curve, suggesting desensitisation at higher concentrations. This is supported by analysis of repetitive stimulation with (-)-nicotine and (-)-cytisine: S2/S1 ratios declined sharply with increasing concentration, whereas subsequent KC1-evoked release remained constant. These results are discussed in terms of possible nicotinic receptor subtypes that might be present on hippocampal nerve terminals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.