ArticleDiabetologia1996
Mast cells and type VIII collagen in human diabetic nephropathy.
Article in Diabetologia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- Role of Mast Cells and Their Mediators in Chronic Kidney Diseases.International journal of molecular sciences · 2025Review
- Identification of Lipotoxicity-Related Biomarkers in Diabetic Nephropathy Based on Bioinformatic Analysis.Journal of diabetes research · 2024Article
- FTIR Analysis of Renal Tissue for the Assessment of Hypertensive Organ Damage and proANPInternational journal of molecular sciences · 2023Article
- Development of a Biomarker Panel to Distinguish Risk of Progressive Chronic Kidney Disease.Biomedicines · 2020Article
- Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease.Translational andrology and urology · 2019Review
- House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population.Scientific reports · 2018Article
- Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets.American journal of physiology. Renal physiology · 2017Review
- Overexpression of histamine H₄ receptors in the kidney of diabetic rat.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Pathogenic role of mast cells in the development of diabetic nephropathy: a study of patients at different stages of the disease.Diabetologia · 2012Article
- Impact of Mast Cell Chymase on Renal Disease Progression.Current hypertension reviews · 2012Article
- Mast cells and metabolic syndrome.Biochimica et biophysica acta · 2012Review
- Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model.American journal of physiology. Renal physiology · 2012Article
- Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans.Frontiers in immunology · 2012Article
- Role of mast cells, stem cell factor and protease-activated receptor-2 in tubulointerstitial lesions in IgA nephropathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Do resident renal mast cells play a role in the pathogenesis of diabetic nephropathy?Molecular and cellular biochemistry · 2009Review
- Article
- Leukocytes in glomerular injury.Seminars in immunopathology · 2007Review
- Chymase increases glomerular albumin permeability via protease-activated receptor-2.Molecular and cellular biochemistry · 2007Article
- Increased expression of mast cells in reflux nephropathy.Pediatric nephrology (Berlin, Germany) · 2004Article
- Key role of mast cells and their major secretory products in inflammatory bowel disease.World journal of gastroenterology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal injury in diabetes mellitus is associated with progressive interstitial fibrosis and extracellular matrix accumulation. However, the phenotypes of cells forming the interstitial infiltrate in diabetic nephropathy have not been precisely defined. There is increasing evidence for the association of mast cells with angiogenesis, chronic inflammatory conditions and fibrosis. We have recently shown that human mast cells can produce the non-fibrillar short chain type VIII collagen in vivo. Using immunohistochemistry, in situ hybridisation and reverse transcriptase-polymerase chain reaction, we examined the contribution of mast cells and type VIII collagen to the fibrotic changes occurring in biopsy-proven diabetic nephropathy. We observed that the number of interstitial mast cells was significantly increased in diabetic nephropathy compared with normal kidney tissue. In specimens from diabetic subjects, intense immunohistochemical staining for type VIII collagen was detected in mast cells, on periglomerular fibres and in perivascular and interstitial sites. The expression of type VIII collagen in periglomerular and interstitial sites coincided with that of alpha smooth muscle actin, a marker for myofibroblastic differentiation mRNA for type VIII collagen was detected by reverse transcriptase-polymerase chain reaction in diabetic nephropathy and in a human mast cell line. By in situ hybridisation the transcripts for type VIII collagen were localised to renal mast cells. The increased number of mast cells and the elevated type VIII collagen deposition in human diabetic nephropathy provides a potential link between the extracellular matrix accumulation and the fibrosis observed in this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.