ArticleThe Journal of cell biology1996
Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Nuclear speckles: a fundamental layer of gene regulation.Trends in cell biology · 2026Review
- Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.PLoS pathogens · 2026Article
- Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.bioRxiv : the preprint server for biology · 2026Article
- Nuclear speckles - a driving force in gene expression.Journal of cell science · 2022Review
- Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells.Journal of virology · 2016Article
- Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.PLoS pathogens · 2008Article
- Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts.Journal of virology · 2006Article
- Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells.The Journal of cell biology · 2004Article
- In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei.RNA (New York, N.Y.) · 2004Article
- Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.Journal of virology · 2002Article
- Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain.The Journal of cell biology · 2000Article
- Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.Molecular biology of the cell · 2000Article
- Electron tomography reveals posttranscriptional binding of pre-mRNPs to specific fibers in the nucleoplasm.The Journal of cell biology · 2000Article
- Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles.The Journal of cell biology · 1999Article
- Organization of highly acetylated chromatin around sites of heterogeneous nuclear RNA accumulation.Molecular biology of the cell · 1998Article
- Microinjection of anti-coilin antibodies affects the structure of coiled bodies.The Journal of cell biology · 1998Article
- Localization of hepatitis delta virus RNA in the nucleus of human cells.RNA (New York, N.Y.) · 1998Article
- The tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export.Journal of virology · 1998Article
- Targeting of U2AF65 to sites of active splicing in the nucleus.The Journal of cell biology · 1997Article
- Modification of Nuclear Compartments and the 3D Genome in the Course of a Viral Infection.Acta naturaeArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posttranscriptional steps in the production of mRNA include well characterized polyadenylation and splicing reactions, but it is also necessary to understand how RNA is transported within the nucleus from the site of its transcription to the nuclear pore, where it is translocated to the cytoplasmic compartment. Determining the localization of RNA within the nucleus is an important aspect of understanding RNA production and may provide clues for investigating the trafficking of RNA within the nucleus and the mechanism for its export to the cytoplasm. We have previously shown that late phase adenovirus-infected cells contain large clusters of snRNP and non-snRNP splicing factors; the presence of these structures is correlated with high levels of viral late gene transcription. The snRNP clusters correspond to enlarged interchromatin granules present in late phase infected cells. Here we show that polyadenylated RNA and spliced tripartite leader exons from the viral major late transcription unit are present in these same late phase snRNP-containing structures. We find that the majority of the steady state viral RNA present in the nucleus is spliced at the tripartite leader exons. Tripartite leader exons are efficiently exported from the nucleus at a time when we detect their accumulation in interchromatin granule clusters. Since the enlarged interchromatin granules contain spliced and polyadenylated RNA, we suggest that viral RNA may accumulate in this late phase structure during an intranuclear step in RNA transport.
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