ArticleThe EMBO journal1996
Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in lung of male Wistar rats.Toxicology reports · 2019Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Intra- and intermolecular regulatory interactions in Upf1, the RNA helicase central to nonsense-mediated mRNA decay in yeast.Molecular and cellular biology · 2013Article
- A rapid, inexpensive yeast-based dual-fluorescence assay of programmed--1 ribosomal frameshifting for high-throughput screening.Nucleic acids research · 2011Article
- Translational errors: from yeast to new therapeutic targets.FEMS yeast research · 2010Review
- Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins.Journal of virology · 2010Article
- Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit.Nucleic acids research · 2008Article
- Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.RNA (New York, N.Y.) · 2004Article
- A programmed -1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element.Nucleic acids research · 2004Article
- Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2003Article
- Delayed rRNA processing results in significant ribosome biogenesis and functional defects.Molecular and cellular biology · 2003Article
- The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Saturation mutagenesis of 5S rRNA in Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Molecular and cellular biology · 2001Article
- Ribosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2001Article
- Comparative mutational analysis of cis-acting RNA signals for translational frameshifting in HIV-1 and HTLV-2.Nucleic acids research · 2001Article
- Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).Molecular and cellular biology · 2001Article
- Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway.RNA (New York, N.Y.) · 2001Article
- Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.RNA (New York, N.Y.) · 2000Article
- Nonsense-mediated decay mutants do not affect programmed -1 frameshifting.RNA (New York, N.Y.) · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mof4-1 (maintenance of frame) allele in the yeast Saccharomyces cerevisiae was isolated as a chromosomal mutation that increased the efficiency of -1 ribosomal frameshifting at the L-A virus frameshift site and caused loss of M1, the satellite virus of L-A. Here, we demonstrate that strains harboring the mof4-1 allele inactivated the nonsense-mediated mRNA decay pathway. The MOF4 gene was shown to be allelic to UPF1, a gene whose product is involved in the nonsense-mediated mRNA decay pathway. Although cells harboring the mof4-1 allele of the UPF1 gene lose the M1 virus, mutations in other UPF genes involved in nonsense-mediated mRNA decay maintain the M1 virus. The mof4-1 strain is more sensitive to the aminoglycoside antibiotic paromomycin than a upf1 delta strain, and frameshifting efficiency increases in a mof4-1 strain grown in the presence of this drug. Further, the ifs1 and ifs2 alleles previously identified as mutations that enhance frameshifting were shown to be allelic to the UPF2 and UPF1 genes, respectively, and both ifs strains maintained M1. These results indicate that mof4-1 is a unique allele of the UPF1 gene and that the gene product of the mof4-1 allele affects both -1 ribosomal frameshifting and mRNA turnover.
Indexed as
Identifiers
8896465PMC452316W1887488508What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.