ArticleThe EMBO journal1996
The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 100 citations in OpenAlex.
- Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.Nature communications · 2024Article
- Structure of the transcribing RNA polymerase II-Elongin complex.Nature structural & molecular biology · 2023Article
- Article
- ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer.Cancer medicine · 2023Article
- The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder.Biochemical Society transactions · 2023Review
- Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Lysine methylation signaling of non-histone proteins in the nucleus.Cellular and molecular life sciences : CMLS · 2019Review
- Elongin B is a binding partner of the male germ cell nuclear speckle protein sperm-associated antigen 16S (SPAG16S) and is regulated post-transcriptionally in the testis.Reproduction, fertility, and development · 2019Article
- Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.Molecular cell · 2017Article
- Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.The Journal of biological chemistry · 2017Article
- EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.Molecular cell · 2016Article
- Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses.The Journal of biological chemistry · 2015Article
- Review
- Transcriptional properties of mammalian elongin A and its role in stress response.The Journal of biological chemistry · 2013Article
- The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings.PloS one · 2013Article
- The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1.Biochemistry research international · 2012Article
- Efficient and rapid nucleosome traversal by RNA polymerase II depends on a combination of transcript elongation factors.The Journal of biological chemistry · 2011Article
- Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.The EMBO journal · 2008Article
- ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.Molecular and cellular biology · 2007Article
- SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The elongin (SIII) complex strongly stimulates the rate of elongation by RNA polymerase II by suppressing transient pausing by polymerase at many sites along the DNA. Elongin (SIII) is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, which bind stably to each other to form a binary complex that interacts with elongin A and strongly induces its transcriptional activity. The elongin (SIII) complex is a potential target for negative regulation by the von Hippel-Lindau (VHL) tumor suppressor protein, which is capable of binding stably to the elongin BC complex and preventing it from activating elongin A. Here, we identify an elongin A domain sufficient for activation of elongation and demonstrate that it is a novel type of inducible activator that targets the RNA polymerase II elongation complex and is evolutionarily conserved in species as distantly related as Caenorhabditis elegans and man. In addition, we demonstrate that both the elongin A elongation activation domain and the VHL tumor suppressor protein interact with the elongin BC complex through a conserved elongin BC binding site motif that is essential for induction of elongin A activity by elongin BC and for tumor suppression by the VHL protein.
Indexed as
Identifiers
8896449PMC452300W130301589What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.