ArticleArchives of virology1996
G3P2 rotaviruses causing diarrhoeal disease in neonates differ in VP4, VP7 and NSP4 sequence from G3P2 strains causing asymptomatic neonatal infection.
Article in Archives of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Genetic Diversity of Human Rotavirus A Among Hospitalized Children Under-5 Years in Lebanon.Frontiers in immunology · 2020Article
- Relative roles of GM1 ganglioside, N-acylneuraminic acids, and α2β1 integrin in mediating rotavirus infection.Journal of virology · 2014Article
- Article
- Clinical and molecular observations of two fatal cases of rotavirus-associated enteritis in children in Italy.Journal of clinical microbiology · 2011Article
- Conformational Differences Unfold a Wide Range of Enterotoxigenic Abilities Exhibited by rNSP4 Peptides from Different Rotavirus Strains.The open virology journal · 2011Article
- Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116E.Virology · 2010Article
- N- and C-terminal cooperation in rotavirus enterotoxin: novel mechanism of modulation of the properties of a multifunctional protein by a structurally and functionally overlapping conformational domain.Journal of virology · 2006Article
- Sequencing and phylogenetic analysis of human genotype P[6] rotavirus strains detected in Hungary provides evidence for genetic heterogeneity within the P[6] VP4 gene.Journal of clinical microbiology · 2004Article
- Rotavirus serotype G9P[8] and acute gastroenteritis outbreak in children, Northern Australia.Emerging infectious diseases · 2004Article
- Evidence for genetic linkage between the gene segments encoding NSP4 and VP6 proteins in common and reassortant human rotavirus strains.Journal of clinical microbiology · 2003Article
- A human vaccine strain of lamb rotavirus (Chinese) NSP4 gene: complete nucleotide sequence and phylogenetic analyses.Virus genes · 2003Article
- Detection and characterization of rotaviruses in hospitalized neonates in Blantyre, Malawi.Journal of clinical microbiology · 2002Article
- Diversity within the VP4 gene of rotavirus P[8] strains: implications for reverse transcription-PCR genotyping.Journal of clinical microbiology · 2000Article
- Isolation of a human rotavirus strain with a super-short RNA pattern and a new P2 subtype.Journal of clinical microbiology · 1999Article
- Sequence analysis of the NSP4 gene from human rotavirus strains isolated in the United States.Virus genes · 1999Article
- Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.Journal of virology · 1998Article
- Mutations in rotavirus nonstructural glycoprotein NSP4 are associated with altered virus virulence.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During longitudinal epidemiological studies of rotavirus infections in children in Melbourne, Australia human G3P2 rotavirus strains causing asymptomatic or symptomatic infections have been identified. Eleven strains (AS strains) associated with asymptomatic infection of newborn babies from 1974-1984, and five strains (S strains) associated with symptomatic infection of newborn babies (4) or a 22 week old infant (1) during 1980-1986 were studied. The entire nucleotide sequences of genes coding for VP4, VP7, NSP4 and VP6 were derived for representative AS and S strains. The nucleotide sequences of neutralization epitope regions present on the outer capsid proteins VP4 and VP7 (regions C and F) showed extensive conservation of nucleotide and deduced amino acid sequence in all strains. Minor variations were observed over the 12 year period in VP7 epitope regions A and B in some strains. Specific conserved amino acids differences between the asymptomatic and symptomatic strains were observed in the genes encoding VP4 at aa133 and 303 (asparagine or threonine) and 380 (serine or isoleucine), VP7 at aa27 (threonine or isoleucine), aa29 (isoleucine or threonine), aa42 (valine or alanine) and aa238 (asparagine or aspartic acid/serine) and NSP4 at aa135 (isoleucine or valine). No amino acid changes were identified in gene 6. The observed amino acid differences occurred in proteins that have been implicated in virulence, and correlate with differences in clinical symptoms of infants infected with these strains. These results permit speculation about the genetic basis for virulence of human strains.
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