Trial reportExperimental brain research1996
The "gap paradigm" leads to express-like saccadic reaction times in Parkinson's disease.
Trial report in Experimental brain research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Saccadic eye movements in neurological disease: cognitive mechanisms and clinical applications.Journal of neurology · 2025Review
- Modeling saccade reaction time in marmosets: the contribution of earlier visual response and variable inhibition.Frontiers in systems neuroscience · 2024Article
- Circuits for Action and Cognition: A View from the Superior Colliculus.Annual review of vision science · 2017Review
- What do eye movements tell us about patients with neurological disorders? - An introduction to saccade recording in the clinical setting.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: a clinical review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013Review
- Impaired conflict monitoring in Parkinson's disease patients during an oculomotor redirect task.Experimental brain research · 2011Article
- Spread deficits in initiation, speed and accuracy of horizontal and vertical automatic saccades in dementia with lewy bodies.Frontiers in neurology · 2010Article
- Impaired inhibitory oculomotor control in patients with Parkinson's disease.Experimental brain research · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Application of the "gap paradigm" reduces mean saccadic reaction time (SRT). It enhances oculomotor response, sometimes showing express-like reactions within about 100-140 ms from target onset, which are called "express saccades." Despite some controversy, there is evidence that express and regular saccades may be controlled by different pathways, but it is still not clear which pathways are involved in the generation of express saccades. It was suggested that the substantia nigra (SN) could take part in the control of these saccades. We compared saccadic reaction times of 14 patients with mild to moderate Parkinson's disease (PD), which commonly affects the SN, with those of nine elderly normal subjects. The results show a clear gap effect and no significant difference between mean saccadic reaction times and reaction time distributions of the PD and the control group. In the gap condition, express saccades are present in several subjects of both groups. Therefore, it is concluded that the deficits in the SN pars compacta due to PD, which affect directly and indirectly the activity of the SN pars reticulata that projects to SC, do not dominantly influence the process of preparing and executing express and regular saccades in patients with mild to moderate PD.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.