ArticleAntimicrobial agents and chemotherapy1996
Characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase gene from Mycobacterium fortuitum.
Article in Antimicrobial agents and chemotherapy, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes.Scientific reports · 2021Article
- Review
- Identification and Characterization of a Novel Chromosomal Aminoglycoside 2'-Frontiers in microbiology · 2021Article
- Structural and biochemical analyses of an aminoglycoside 2'-N-acetyltransferase from Mycolicibacterium smegmatis.Scientific reports · 2020Article
- Small-Molecule Acetylation by GCN5-RelatedMicrobiology and molecular biology reviews : MMBR · 2020Review
- Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles.Frontiers in microbiology · 2019Article
- Biofilms on Hospital Shower Hoses: Characterization and Implications for Nosocomial Infections.Applied and environmental microbiology · 2016Article
- Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.Biochemistry · 2016Review
- Molecular biology of drug resistance in Mycobacterium tuberculosis.Current topics in microbiology and immunology · 2013Review
- Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Clinical microbiology reviews · 2012Review
- Novel streptomycin resistance gene from Mycobacterium fortuitum.Antimicrobial agents and chemotherapy · 2006Article
- Versatility of aminoglycosides and prospects for their future.Clinical microbiology reviews · 2003Review
- Tandem amplification of a 28-kilobase region from the Yersinia enterocolitica chromosome containing the blaA gene.Antimicrobial agents and chemotherapy · 2003Article
- Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.Antimicrobial agents and chemotherapy · 2000Article
- Aminoglycoside resistance in Mycobacterium kansasii, Mycobacterium avium-M. intracellulare, and Mycobacterium fortuitum: are aminoglycoside-modifying enzymes responsible?Antimicrobial agents and chemotherapy · 2000Article
- RecA-Mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA.Antimicrobial agents and chemotherapy · 1999Article
- Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis.Journal of bacteriology · 1998Article
- Characterization of gentamicin 2'-N-acetyltransferase from Providencia stuartii: its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan.Journal of bacteriology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel gene encoding an aminoglycoside 2'-N-acetyltransferase (AAC) was cloned from Mycobacterium fortuitum. DNA sequencing results identified an open reading frame that we have called aac(2')-Ib encoding a putative protein with a predicted molecular mass of 24,800 Da. The deduced AAC(2')-Ib protein showed homology to the AAC(2')-Ia from Providencia stuartii. This is the second member of a subfamily of AAC(2')-I enzymes to be identified. No homology was found with other acetyltransferases, including all of the AAC(3) and AAC(6') proteins. The aac(2')-Ib gene cloned in a mycobacterial plasmid and introduced in Mycobacterium smegmatis conferred resistance to gentamicin, tobramycin, dibekacin, netilmicin, and 6'-N-ethylnetilmicin. DNA hybridization with an intragenic probe of aac(2')-Ib showed that this gene was present in all 34 strains of M. fortuitum tested. The universal presence of the aac(2')-Ib gene in M. fortuitum was not correlated with any aminoglycoside resistance phenotype, suggesting that this gene may play a role in the secondary metabolism of the bacterium.
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