ArticleInfection and immunity1996
Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Public health data collected by PulseNet support a role forMicrobiology spectrum · 2026Article
- Unveiling the novel regulatory roles of RpoD-family sigma factors in Salmonella Typhimurium heat shock response through systems biology approaches.PLoS genetics · 2024Article
- Succinate utilisation by Salmonella is inhibited by multiple regulatory systems.PLoS genetics · 2024Article
- OmpR and Prc contribute to switch the Salmonella morphogenetic program in response to phagosome cues.Molecular microbiology · 2022Article
- Article
- Functions of Small Non-Coding RNAs inBiology · 2022Review
- Impact of the Resistance Responses to Stress Conditions Encountered in Food and Food Processing Environments on the Virulence and Growth Fitness of Non-TyphoidalFoods (Basel, Switzerland) · 2021Review
- RpoS-regulatedVirulence · 2020Article
- Antibiotic Killing of Diversely Generated Populations of Nonreplicating Bacteria.Antimicrobial agents and chemotherapy · 2019Article
- Role of CsrA in stress responses and metabolism important for Salmonella virulence revealed by integrated transcriptomics.PloS one · 2019Article
- A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells.Oncotarget · 2016Article
- Genome sequencing and analysis of Salmonella enterica serovar Typhi strain CR0063 representing a carrier individual during an outbreak of typhoid fever in Kelantan, Malaysia.Gut pathogens · 2012Article
- Characterization and differential gene expression between two phenotypic phase variants in Salmonella enterica serovar Typhimurium.PloS one · 2012Article
- Intraspecies variation in the emergence of hyperinfectious bacterial strains in nature.PLoS pathogens · 2012Article
- The Role of the spv Genes in Salmonella Pathogenesis.Frontiers in microbiology · 2011Article
- Role of RpoS in virulence of pathogens.Infection and immunity · 2010Review
- Environmental and intracellular regulation of Francisella tularensis ripA.BMC microbiology · 2009Article
- High-throughput bioluminescence-based mutant screening strategy for identification of bacterial virulence genes.Applied and environmental microbiology · 2009Article
- Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence.The Journal of biological chemistry · 2008Article
- Induction of RpoS degradation by the two-component system regulator RstA in Salmonella enterica.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during starvation and stress conditions and is required for virulence in Salmonella spp. We have used lacZ reporter fusions to rpoS and rpoS-dependent genes to study rpoS regulation after entry of Salmonella typhimurium into macrophages and epithelial cells. The results demonstrate that expression of an rpoS::lacZ translational fusion increases rapidly in S. typhimurium after phagocytosis. Activity of RpoS also increases after bacterial entry into both macrophages and epithelial cells, as demonstrated by the induction of the rpoS-regulated genes katE and spvB. A control rpoS-independent promoter for neomycin resistance does not show significant induction after cell entry. These results demonstrate that the regulatory system mediated by RpoS in S. typhimurium is activated by the intracellular environment of eukaryotic cells.
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